Correlation between high on-treatment platelet reactivity and in-stent restenosis in patients with coronary atherosclerotic heart disease complicated with type 2 diabetes mellitus undergoing percutaneous coronary intervention
Hu Chengping
Qin Zheng
Du Yu
Zhu Yong
Shi Chao
Zhao Yingxin
Abstract：Objective To explore the correlation between high on-treatment platelet reactivity(HPR) and in-stent restenosis(ISR) in patients with coronary atherosclerotic heart disease (CHD) complicated with type 2 diabetes mellitus undergoing percutaneous coronary intervention (PCI).Methods Clinical data of 395 patients with CHD and type 2 diabetes who underwent PCI from January 2010 to December 2014 in Beijing Anzhen Hospital,Capital Medical University were retrospectively analyzed;51 patients had ISR (ISR group) and 344 patients were included in non-ISR group.Clinical baseline data,biochemical indicators and coronary angiography results were recorded.The predictive value of HPR for ISR was analyzed by receiver operating characteristic(ROC) curve.The relevance between HPR and ISR was analyzed by multivariate logistic regression.Results The maximum platelet aggregation rate (MPAR) and platelet distribution width in ISR group were significantly higher than those in non-ISR group[(55 ±17)％ vs (42 ±16)％,(13.7 ±2.4)％ vs (12.8 ±2.4)％] (P＜0.05).The area under ROC curve was 0.71 (95％ confidence interval:0.635-0.793,P ＜0.001) when MPAR ＞56.5％ was used as the diagnostic criteria of HPR.The sensitivity and specificity of HPR in predicting the occurrence of ISR were 53.0％ and 82.0％,respectively.Totally 93 patients(23.5％) had HPR;the HPR rate in ISR group was significantly higher than that in non-ISR group[52.9％ (27/51) vs 19.2％ (66/344)] (P ＜0.05).Logistic regression analysis showed that HPR was an independent risk factor of ISR(odds ratio =5.971,95％ confidence interval:2.900-12.292,P ＜ 0.001).Conclusion HPR is an independent predictor of ISR in CHD patients with type 2 diabetes.
Keywords：Coronary atherosclerotic heart diseasePlatelet reactivityIn-stent restenosis
Publication Date：2017-09-30
Online Publishing Date：2026-09-14(First online date of this platform, not the publication date of the document)
Pages：4( 1290-1293 )