Clinical effect of salmeterol xinafoat and fluticasone propionate powder for inhalation combined with non-invasive positive pressure ventilation on chronic obstructive pulmonary disease complicated with respiratory failure in elderly patients
Li Gaiping
Liu Yu
Xu Yanjie
Yu Jianmin
Abstract：Objective To analyze the effectiveness and safety of salmeterol xinafoat and fluticasone propionate powder for inhalation combined with non-invasive positive pressure ventilation in treatment of elderly patients with chronic obstructive pulmonary disease (COPD) complicated with respiratory failure.Methods A total of 90 COPD patients with respiratory failure from January 2014 to January 2016 in January in the 309th Hospital of Chinese People's Liberation Army were randomly divided into routine group and combination group,with 45 cases in each group.Both groups had supportive therapy and non-invasive positive ventilation;the combination group had salmeterol xinafoat and fluticasone propionate powder for inhalation for 7 d.Blood-gas indexes [arterial partial pressure of oxygen(PaO2),arterial partial pressure of carbon dioxide(PaCO2),oxygen saturation(SpO2)],lung ventilation function indexes[forced expiratory volume in 1 second(FEV1),forced vital capacity(FVC),FEV1/FVC,FEV1 change in percentage predicted value(FEV1％),inspiratory capacity(IC),residual volume(RV),functional residual capacity(FRC)],clinical effective rate and adverse reactions were analyzed.Results After treatment,PaO2,PaCO2,SpO2,FEV1,FVC,FEV1/FVC,FEV1％,IC,RV and FRC in combination group were significantly better than those in routine group[(92 ±7)mmHg vs (83 ±8)mmHg,(37 ±7)mmHg vs (42 ±7)mmHg,(96 ± 7)％ vs (91 ±6)％,(2.49 ±0.35)L vs (1.09 ±0.24)L,(3.3 ±0.8)L vs (2.2 ±0.9)L,(66 ± 10)％ vs (46 ±9)％,(68 ± 13)％ vs (54 ± 12)％,(2.88 ±0.16)L vs (1.55 ±0.24) L,(3.96 ±0.88)L vs (2.85 ± 0.74)L,(3.3 ±0.6)L vs (2.2 ±0.6)L] (P ＜0.05).The total effective rate in combination group was significantly higher than that in routine group [93.3 ％ (42/45) vs 77.8 ％ (35/45)] (P ＜ 0.05).The incidence of adverse reactions had no significant difference between groups(P ＞0.05).Conclusion Salmeterol xinafoat and fluticasone propionate powder for inhalation combined with non-invasive ventilation treating elderly COPD with respiratory failure can effectively improve blood-gas and lung function with few side effects.
Keywords：Chronic obstructive pulmonary diseaseRespiratory failureNon-invasive positive pressure ventilationSalmeterol xinafoat and fluticasone propionate powder for inhalation
Publication Date：2017-01-01
Online Publishing Date：2026-09-14(First online date of this platform, not the publication date of the document)
Pages：4( 1153-1156 )