Relevance among serum anion gap, severity of coronary stenosis and all-cause mortality in coronary heart disease
Yang Shiwei
Zhou Yujie
Zhao Yingxin
Liu Yuyang
Zhou Zhiming
Jia Dean
Hu Bin
Shen Hua
Gao Fei
Ma Qian
Han Hongya
Wang Zhijian
Abstract：Objective To explore the relevance among serum anion gap(AG),severity of coronary stenosis and all-cause mortality in patients with coronary heart disease (CHD).Methods Totally 18 115 patients with CHD were enrolled at 5 hospitals from April 2004 to October 2010.The serum level of AG was calculated in all patients;the severity of coronary stenosis was defined according to numbers of stenosis vessels and the SYNTAX score.Relations among serum AG,severity of coronary stenosis and postoperative 30 d all-cause mortality were analyzed.Results There were 4 510 patients(24.9％) had serum AG ＞ 16 mmol/L.The patients were divided into Q1 group(AG＜ 11.40 mmol/L,n=4 537),Q2 group(11.40 mmol/L≤AG ＜ 13.52 mmol/L,n =4 558),Q3 group(13.52 mmol/L≤AG ＜ 15.92 mmol/L,n =4 508) and Q4 group(AG≥15.92 mmol/L,n =4 512) according to the quartile values of AG.No correlation was observed between serum AG and severity of coronary stenosis(P ＞ 0.05).Serum AG was an independent predictor of postoperative 30 d all-cause mortality;the all-cause mortality risk in Q3 and Q4 group significantly increased compared to that in Q1 group (P ＜ 0.05).Conclusion Elevated level of serum AG is associated with the risk of all-cause mortality but not the severity of coronary stenosis in patients with CHD.
Keywords：Coronary heart diseaseAnion gapCoronary artery stenosisAll-cause death
Publication Date：2017-08-30
Online Publishing Date：2026-09-14(First online date of this platform, not the publication date of the document)
Pages：4( 1121-1124 )