Effectiveness and safety of different regimens of tranexamic acid on perioperative blood loss in patients with total knee arthroplasty
Wang Zhenwei
Ai Di
Li Hongchuan
Yu Fang
Yao Qi
Abstract：Objective To investigate the effect and safety of different regimens of tranexamic acid on perioperative blood loss in patients with total knee arthroplasty(TKA).Methods A prospective study was carried out in 90 patients who had unilateral TKA for end-stage knee osteoarthritis from March 2016 to February 2017 in Beijing Shijitan Hospital,Capital Medical University.The patients were randomly divided into 3 groups;the single-use group had 15 mg/kg tranexamic acid by intravenous infusion 10 rmin before the end of operation;the repeated-use group had 15 mg/kg tranexamic acid by intravenous infusion 1 h before operation and 10 min before the end of operation;the control group had no special drug administration.Hemoglobin concentration and hematocrit before and on the 3rd day after operation,postoperative drainage,blood transfusion volume and adverse manifestations of deep venous thrombosis (DVT) were observed.Doppler ultrasonography on lower limb vessels was performed before and 14 d after operation.Results Postoperative drainage volume and total blood loss in singleuse group and repeated-use group were significantly less than those in control group [(253 ± 79),(165 ± 83) ml vs (463 ± 174) ml;(865 ± 241),(742 ± 213) ml vs (1 132 ± 319) ml];there were differences between single-use group and repeated-use group(P ＜ 0.01 or P ＜ 0.05).There was no significant difference of hidden blood loss among groups(P ＞0.05).The blood transfusion rate was 23.3％ (7/30) in single-use group,13.3％ (4/30) in repeated-use group and 43.3％ (13/30) in control group;there were differences among 3 group (P ＜ 0.05).No symptomatic DVT was observed within 14 d after operation.Conclusion Intravenous infusion of tranexamic acid can decrease postoperative drainage,blood loss and blood transfusion without increasing risk of DVT in patients with TKA.
Keywords：Knee arthroplastyTranexamic acidBlood lossProspective study
Publication Date：2017-07-30
Online Publishing Date：2026-09-14(First online date of this platform, not the publication date of the document)
Pages：4( 1029-1032 )