Effect of blood purification on delayed excretion of methotrexate
Wang Xiaofei
Yang Jie
Zhang Liping
Zhang Wei
Ding Zhimin
Zhang Qing
Abstract：Objective To observe the effect of blood purification on delayed excretion of methotrexate (MTX).Methods Three female children with osteosarcoma at Beijing Jishuitan Hospital from February 2011 to June 2014 were retrospectively analyzed.Results The children had vigorous hydration and alkalinization therapy;calcium folinate were used after high-dose MTX administration.Two children had MTX delayed excretion complicated with kidney injury,severe acute liver injury and myelosuppression;1 child had MTX delayed excretion complicated with liver injury.The 3 children had the first time of hemodialysis + hemoperfusion,highflux hemodialysis + hemoperfusion and hemofiltration + hemoperfusion at 38.0 h,48.0 h,4.0 h after MTX administration,respectively;they had 7 rounds of blood purification in total.The children with hemofiltration + hemoperfusion had the highest decline rate of MTX blood concentration.One child had relapse after treatment.Conclusion Early blood purification therapy is effective in the management of delayed MTX excretion and bone marrow suppression;the combination of hemodialysis and hemoperfusion can lower the blood concentration of MTX.
Keywords：OsteosarcomaMethotrexateDelayed excretionBlood purificationHemoperfusion
Publication Date：2017-01-01
Online Publishing Date：2026-09-14(First online date of this platform, not the publication date of the document)
Pages：4( 1022-1025 )