Incidence, predictors and prognosis of major bleeding events after percutaneous coronary intervention in treating non-ST-segment elevated acute coronary syndrome
Liu Ran
Zhao Guanqi
Zheng Wen
Wang Xiao
Zhao Xuedong
Zhou Shenghui
Nie Shaoping
Abstract：Objective To investigate the incidence,predictors and prognosis of major bleeding events in patients with non-ST-elevation acute coronary syndrome (NSTE-ACS) after percutaneous coronary intervention (PCI).Methods Totally 3 817 NSTE-ACS patients who had PCI with drug eluting stent implantation from January to June 2015 in Beijing Anzhen Hospital,Capital Medical University were retrospectively analyzed.Post PCI major bleeding(PPMB),all-cause mortality and major adverse cardiac events(MACE) during 1 year follow-up were analyzed.Results PPMB occurred in 50 cases(1.3％) during 1 year follow-up.Female,baseline systolic blood pressure ≤ 120 mmHg,baseline heart rate ＞ 80 times/min,coronary revascularization history,peptic ulcer history,femoral artery puncture history,use of dual antiplatelet therapy + glycoprotein Ⅱb/Ⅲa receptor antagonist + low molecular heparin/fondaparinux antithrombotic therapy were independent risk factors of 1 year PPMB (P ＝ 0.05).PPMB was significantly correlated with 30 d,1 year all-cause mortality and 30 d MACE (P ＜ 0.05).Conclusion The 1 year incidence of PPMB in patients with NSTE-ACS was 1.3％;bleeding-related adverse outcomes mostly occur during the first 30 days after PCI.
Keywords：Non-ST-elevation acute coronary syndromeHemorrhageAll-cause mortality
Publication Date：2017-07-30
Online Publishing Date：2026-09-14(First online date of this platform, not the publication date of the document)
Pages：5( 978-982 )