Relation between neovascularization of carotid plaques evaluated by contrast-enhanced ultrasound and blood lipid in patients with coronary atherosclerotic heart disease
Zhao Jun
Pan Mingkang
Zhang Fengxiu
Zhang Yu
Chen Lingli
Abstract：Objective To observe neovascularization of carotid plaques in patients with coronary athero sclerotic heart disease(CHD) by contrast-enhanced ultrasound and to analyze the relation between neovascularization and blood lipid level.Methods Totally 118 patients with carotid atherosclerotic plaques (the highest thickness≥2.0 mm) in Zhongguancun Hospital,Chinese Academy of Sciences were enrolled from December 2012 to December 2016;59 patients had CHD(CHD group);59 patients without CHD were enrolled as control group.All patients had contrast-enhanced ultrasound examination;plaques formation,ultrasound enhancement rate,peak time of plaque,maximum peak intensity ratio and area under the curve were measured.Levels of triacylglycerol,total cholesterol,low density lipoprotein cholesterol(LDL-C) and high density lipoprotein cholesterol were tested.Results One hundred and ninety-three plaques were detected in CHD Group;164 plaques were detected in control group.The soft plaque rate and ultrasound enhancement rate in CHD group were significantly higher than those in control group[50.8％ (98/193) vs 31.7％ (52/164),73.1％ (141/193) vs 43.9％ (72/164)] (P ＜ 0.05).Peak time of plaque in CHD group was significantly shorter,maximum peak intensity ratio and area under the curve were higher than those in control group [(16.8 ± 1.9) s vs (19.0 ± 2.4) s,(68 ± 7) ％ vs (59 ± 7) ％,(2 498 ±403)dB/s vs (1 985 ±396)dB/s] (P ＜0.01).Levels of triacylglycerol and LDL-C in CHD group were significantly higher than those in control group [(2.2 ± 1.1) mmol/L vs (1.5 ± 0.8) mmol/L,(3.1 ± 0.8) mmol/L vs (2.2 ± 0.8) mmol/L] (P ＜ 0.05).Conclusion High density of neovascularization in carotid atherosclerotic plaques analyzed by contrast-enhanced ultrasound may be a risk factor of CHD.
Keywords：Coronary artery diseaseCarotid atherosclerosisContrast-enhanced ultrasound
Publication Date：2017-07-30
Online Publishing Date：2026-09-14(First online date of this platform, not the publication date of the document)
Pages：3( 975-977 )