Relation between three biomarkers and prognosis of heart failure
Shi Yali
Kang Junping
Luo Taiyang
Zhang Yin
Lyu Qiang
Liu Xinmin
Dai Tianyi
Zhang Zichuan
Wang Xi
Liu Xiaohui
Abstract：Objective To investigate the relation among soluble growth stimulation express gene 2 protein (sST2),N-terminal pro-brain natriuretic peptide(NT-proBNP),high sensitivity cardiac troponin Ⅰ(hs-cTnⅠ) and prognosis of patients with heart failure.Methods A total of 173 patients with heart failure were enrolled from May 2015 to November 2015 in the Beijing Anzhen Hospital,Capital Medical University.Levels of sST2,NT-proBNP and hs-cTnⅠ were tested on admission.The relation among sST2,NT-proBNP and hs-cTnⅠ with 1 year incidence of major adverse cardiovascular events (MACE) was analyzed.Results During 1 year follow-up,MACE occurred in 52 cases.Levels of sST2,NT-proBNP and hs-cTnⅠ on admission in MACE group(n =52) were significantly higher than those in non-MACE group(n =121) [41.2 (25.5,62.8) μg/L vs 29.1 (21.6,38.8) μg/L,4 758 (1 978,9 000) ng/L vs 2 799 (1 446,6 073) ng/L,0.05 (0.02,0.09) μg/L vs 0.03 (0.01,0.06) μg/L] (P ＜ 0.05).Cox regression analysis showed that the level of sST2 on admission was an independent predictor of MACE(hazard ratio =2.133,confidence interval:1.011-4.502,P =0.047).Receiver operating characteristic curve analysis showed that sST2,NT-proBNP and hs-cTnⅠ were predictive factors of cardiovascular events [area under curve (AUC) =0.660,0.644,0.659];the predictive value of combination of 3 indicators (AUC =0.705) was higher than that of sST2,NT-proBNP and hs-cTnⅠ alone(P =0.013,0.008,0.031).Kaplan-Meier survival analysis showed that the cumulative survival rate in patients with sST2 ≥39.393 μg/L was significandy lower than that in patients with sST2 ＜ 39.393 μg/L(P ＜ 0.05).Conclusion The concentration of sST2 on admission can be an independent predictive factor of prognosis of heart failure;combined detection of sST2,NT-proBNP and hs-cTnⅠ can improve the prediction.
Keywords：Heart failureSoluble growth stimulation express gene 2N-terminal pro-brain natriuretic peptideHigh sensitivity cardiac troponin Ⅰ
Publication Date：2017-07-30
Online Publishing Date：2026-09-14(First online date of this platform, not the publication date of the document)
Pages：5( 970-974 )