Changes and clinical significance of platelet count to neutrophil lymphocyte absolute value ratio and red blood cell volume distribution width in patients with hepatitis B
Wu Meiling
Liu Yun
Wang Xiaorui
Luan Fang
Cheng Shiqing
Song Xiaofei
Wang Yong
Zhang Bingchang
Ju Ying
Abstract：Objective To explore changes and clinical significance of platelet count to neutrophil lymphocyte absolute value ratio (PNR) and red blood cell volume distribution width (RDW) in patients with hepatitis B.Methods From May to July 2016,59 patients with hepatitis B(Hepatitis B group) and 124 healthy volunteers (normal control group) were enrolled in Shandong Provincial Hospital Affiliated to Shandong University;blood routine,liver indexes [alanine aminotransferase (ALT),aspartate aminotransferase (AST),glutamyl transpeptidase (GGT)],high sensitivity hepatitis B virus (HS-HBV) DNA and hepatitis B surface antigen (HBsAg) were tested.Results The value of PNR in hepatitis B group was significantly lower and RDW was significantly higher than those in normal control group [57.33 (45.48,70.95) vs 71.07 (59.84,83.24);12.45％ (12.10％,13.18％) vs 12.30％ (12.00％,12.50％)] (P ＜ 0.05).According to the optimal cutoff value determined by receiver operating characteristic curve,the hepatitis B group were divided into low PNR group (PNR ＜65.55,40 cases) and high PNR group(PNR≥65.55,19 cases),low RDW group(RDW ＜ 12.45,37cases) and high RDW group (RDW ≥ 12.45,22cases).Levels of AST,ALT and GGT had no significant differences between low and high PNR groups(P ＞0.05).Levels of AST,ALT and GGT in high RDW group were significantly higher than those in low RDW group [46.50 (27.75,140.75) U/L vs 25.00 (19.50,31.00) U/L,40.00 (25.75,121.25) U/L vs 22.00 (15.50,36.00) U/L,(45 ± 42) U/L vs (29 ± 20) U/L] (Z =-3.56,-2.63,-2.03;P ＜ 0.05).Values of HS-HBV DNA and HBsAg had no significant differences between low and high RDW groups(P ＞ 0.05).Conclusion PNR and RDW can contribute to the identification of hepatitis B.
Keywords：Hepatitis BPlatelet count and neutrophil lymphocyte ratioRed blood cell volume distribution width
Publication Date：2017-06-30
Online Publishing Date：2026-09-14(First online date of this platform, not the publication date of the document)
Pages：4( 888-891 )