Bacteriological spectrum and drug susceptibility of pathogens causing infection in patients with diabetic foot

Bao Jianling; Maimaitituer Kelimu; Du Guoli; Pu Wen; Jia Chunli

doi:10.3760/cma.j.issn.1673-4777.2017.06.020

Abstract：Objective To investigate the bacteriological spectrum and drug susceptibility of pathogens causing infection in patients with diabetic foot.Methods Sixty patients with diabetic foot were enrolled from January 2013 to July 2016 in the First Mfiliated Hospital of Xinjiang Medical University.Pathogens in secretions were cultivated and drug susceptibilities of pathogens were detected.Bacteriological spectrum,drug susceptibility and white blood cell count (WBC) before and after use of antibacterials were analyzed.Results Positive results of bacteria culture were detected in 55 patients (91.7 ％);cocci accounted for 51.7 ％ (31/60),with staphylococcus aureus as a top majority;bacilli accounted for 38.3％ (23/60),with proteus,escherichia coli and pseudomonas aeruginosa taking majorities;1 case(1.7％) of candida albicans was detected;2 cases (3.3％) were detected as mixed infections.For staphylococcus aureus,the sensitivity to penicillin was significantly lower than that to oxacillin [9.5 ％ (2/21) vs 66.7 ％ (14/21)];the sensitivity of staphylococcus aureus to vancomycin [100％ (21/21)] was significantly higher than the sensitivity to oxacillin(P ＜ 0.05).The sensitivity of cocci to oxacillin was 71.0％ (22/31) and 100.0％ (31/31) to vancomycin.The sensitivity of bacilli to imipenem/cilastatin was significantly higher than that to cefuroxime and aztreonam[100％ (23/23) vs 30.4％ (7/23),43.5％ (10/23)] (P＜ 0.05).Only 31 cases were tested WBC after antibiotics;the average level of WBC and the radio of WBC ＞ 10 × 109/L after treatment were significantly lower than those before treatment [(10 ± 4) × 109/L vs (13 ± 6) × 109/L,45.2％ (14/31) vs 74.2％ (23/31)] (P ＜ O.05).Conclusion Cocci are the dominant pathogens of infection in patients with diabetic foot.