Effects of atorvastatin and rosuvastatin on carotid intima-media thickness and serum type Ⅱ A secretory phospholipase A2 level in elderly patients with hypertension
Mu Jinxing
Chen Yaoqi
Chen Hongbo
Qi Liping
Yang Haiyan
Abstract：Objective To analyze effects of atorvastatin and rosuvastatin on carotid intima-media thickness(IMT) and serum type Ⅱ A secretory phospholipase A2 (sPLA2 Ⅱ A) in elderly patients with hypertension.Methods Totally 90 elderly patients with hypertension from April 2014 to July 2015 in Xingtai Third Hospital of Hebei Province were randomly divided into observation group and control group,with 45 cases in each group.The control group had atorvastatin(10 mg oral before bedtime);the observation group had rosuvastatin (20 mg oral before bedtime);both groups were treated for 1 year.Blood pressure,carotid IMT,serum sPLA2 Ⅱ A,blood glucose,total cholesterol,triacylglycerol and low density lipoprotein cholesterol (LDL-C) were analyzed.Results After treatment,systolic pressure,diastolic pressure and mean arterial pressure had no significant differences between groups (P ＞ 0.05).Values of IMT in observation group and control group after treatment were significantly lower than those before treatment[(1.2 ±0.6) mm vs (1.5 ±0.7) mm,(1.1 ± 0.6) mm vs (1.5 ±0.8)] (P ＜ 0.05);IMT had no significant differences between groups before and after treatment (P ＞ 0.05).Levels of serum sPLA2 Ⅱ A in observation group and control group after treatment were significantly lower than those before treatment [(3.1 ± 0.7) μg/L vs (4.3 ± 1.1) μg/L,(3.2 ± 0.8) μg/L vs (4.4 ± 1.0) μg/L] (P ＜0.05);serum sPLA2 Ⅱ A had no significant differences between groups before and after treatment (P ＞ 0.05).Blood glucose,total cholesterol,triacylglycerol and LDL-C had no significant differences between groups before and after treatment(P ＞ 0.05).Conclusion Atorvastatin and rosuvastatin are effective in treating hypertension in elderly patients;both drugs can prevent the occurrence of atherosclerosis and reduce the level of serum sPLA2 Ⅱ A.
Keywords：HypertensionAtorvastatinRosuvastatinCarotid intima-media thicknessType Ⅱ A secretory phospholipase A2
Publication Date：2017-01-01
Online Publishing Date：2026-09-14(First online date of this platform, not the publication date of the document)
Pages：4( 724-727 )