Effect and mechanisms of angiotensin converting enzyme 2 activation/angiotensin converting enzyme inhibition in prevention of right heart failure in pulmonary artery hypertension
Chen Mengna
Nie Meiling
Zou Xiaozhao
Guo Wen
Zhao Tiefu
Du Xiaobing
Tian Lei
Ma Hanying
Abstract：Objective To investigate the effect and mechanisms of angiotensin converting enzyme(ACE) 2 activation and ACE inhibition in prevention of pulmonary artery hypertension (PAH) induced right heart failure.Methods Thirty-three male SD rats were randomly assigned into blank control group (n =6),PAH induced right heart failure group (n =9),ACE2 agonist (Res) intervention group (n =9) and ACE inhibitor (ACEI) intervention group(n =9).After feeding 6 months,cardio pulmonary function indexes were determined;levels of angiotensin Ⅱ (Ang Ⅱ) and Ang (1-7) in plasma,myocardium of right ventricle and lung tissue were detected;levels of ACE,ACE2,angiotensin type 1 receptor(AT1 R) and Mas protein in myocardium of right ventricle and lung tissue were detected.Results Pulmonary artery flow acceleration time,right ventricular ejection fraction (RVEF) and right ventricular fractional shortening(RVFS) in Res intervention group and ACEI intervention group were significantly higher than those in PAH induced right heart failure group(P ＜ 0.05).Ratios of AngⅡ/Ang(1-7) in plasma,myocardium of right ventricle and lung tissue in Res intervention group and ACEI intervention group were significantly lower than those in PAH induced right heart failure group(P ＜0.05).Levels of ACE2 in myocardium of right ventricle in Res intervention group and ACEI intervention group were significantly higher and ACE,AT1R were significantly lower than those in PAH induced right heart failure group(P ＜0.05);ACE,ACE2,AT1R and Mas protein in lung tissue had no significant differences among groups(P ＜0.05).Conclusion ACE2 activation/ACE inhibition can regulate the renin angiotensin system in PAH induced right heart failure in rats;the local effect on right ventricle is more obvious.
Keywords：Hypertension,pulmonaryHeart failureAngiotensin converting enzyme 2Angiotensin converting enzyme inhibitor
Publication Date：2017-05-30
Online Publishing Date：2026-09-14(First online date of this platform, not the publication date of the document)
Pages：5( 698-702 )