Effect of indapamide combined with levamlodipine on blood lipid and immune function in patients with hypertension complicated with coronary atherosclerotic heart disease

Yang Yayong; Mou Jing

doi:10.3760/cma.j.issn.1673-4777.2017.05.010

Abstract：Objective To analyze the effect of indapamide combined with levamlodipine on blood lipid level and immune function in patients with hypertension complicated with coronary heart disease (CHD).Methods Totally 86 hypertension patients complicated with CHD in Luzhou People's Hospital in Sichuan Province were enrolled from January 2015 to June 2016.The patients were randomly divided into combined treatment group and levamlodipine group,with 43 cases in each group.The levamlodipine group took levamlodipine besylate tablets 5 mg/time,1 time/d;the combined treatment group took levamlodipine besylate tablets and indapamide tablets 2.5 mg/time,1 time/d;the treatments lasted for at least 6 weeks.Mean arterial pressure (MAP),left ventricular ejection fraction (LVEF),total cholesterol (TC),triacylglycerol (TG),immunoglobulin (Ig) G,IgA,IgM,CD3+ and CD4+ were analyzed before and after 3,6 weeks of treatment.Adverse reactions of headache,dizziness and edema were recorded.Results In combined treatment group,MAP,TC,TG,IgG,IgA and IgM after 3,6 weeks of treatment were significantly lower than those before treatment;LVEF,CD3+ and CD4+were significantly higher than those before treatment [(109 ± 16),(87 ± 11) mmHg vs (123 ± 27) mmHg;(4.6 ±0.9),(4.1 ±0.6) mmol/L vs(6.4 ± 1.2) mmol/L;(2.1 ± 0.4),(1.5 ± 0.4) mmol/L vs(3.7 ± 0.6) mmol/L;(11.1±1.2),(9.6±1.0)g/Lvs(14.4±1.7)g/L;(2.68 ±0.35),(2.02±0.25)g/Lvs(3.26±0.51)g/L;(2.42 ±0.28),(2.15 ±0.16)g/L vs(2.87 ±0.32)g/L;(58 ±7)％,(66 ±8)％ vs(50 ±6)％;(57 ±7)％,(63 ±7)％ vs(49±7)％;(28 ±4)％,(35±4)％ vs(24±3)％](P＜0.05).Inlevamlodipinegroup,MAP,TC,TG,IgG,IgA,IgM,LVEF,CD3+ and CD4+ after 6 weeks of treatment showed significant differences compared to those before treatment(P ＜ 0.05).MAP,TC,TG,IgG,IgA and IgM in combined treatment group after 3,6 weeks of treatment were significantly lower than those in levamlodipine group;LVEF,CD3+ and CD4+ in combined treatment group were significantly higher than those in levamlodipine group (P ＜ 0.05).Incidences of headache,dizziness,edema had no significant differences between groups (P ＞ 0.05).Conclusion Indapamide combined with amlodipine treating hypertension complicated with CHD can significantly improve blood pressure,heart function,blood lipid and immune function.