Clinical observation of low dosage esmolol applied in general anesthesia induction in patients with hypertrophic obstructive cardiomyopathy
Zhang Chunlei
Liu Yaguang
Qing Enming
Ma Jun
Abstract：Objective To observe the clinical effect of low dosage esmolol applied in general anesthesia induction of hypertrophic obstructive cardiomyopathy.Methods Totally 56 patients undergoing left ventricular septal myectomy for hypertrophic obstructive cardiomyopathy were enrolled from January 2014 to December 2015 in Beijing Anzhen Hospital,Capital Medical University.The patients were randomly divided into observation group and control group,with 28 cases in each group.The observation group had esmolol 50 μg/kg during anesthesia induction;the control group had the same dosage of 0.9％ sodium chloride.Heart rate (HR),mean arterial pressure (MAP),stroke volume (SV) and systemic circulation vascular peripheral resistance (SVR) were recorded at the time of entering operating room (T0) and after anesthesia induction (T1).Usage of phenylephrine was recorded.Results Gender,age,body height,body mass and the grade of American Society of Anesthesiologists had no significant differences between groups at T0 (P ＞ 0.05).HR,MAP,SV and SVR at T1 were significantly lower than those at T0 in both groups[observation group:(66 ±4)times/min vs (78 ±7)times/min,(69 ±8)mmHg vs (80 ± 11) mmHg,(67 ± 6) ml vs (70 ± 6) ml,(902 ± 73) (Dyn · s)/cm5 vs (1 060 ± 98) (Dyn · s)/cm5;control group:(68 ± 5) times/min vs (76 ± 9) times/min,(64 ± 7) mmHg vs (76 ± 13) mmHg,(62 ± 5) ml vs (66 ±8)ml,(869 ±89) (Dyn · s)/cm5 vs (1 008 ± 121) (Dyn · s)/cm5] (P ＜0.05).Use rates of phenylephrine at T1 were significantly higher than those at T0 in both groups [observation group:3.6％ (1/28) vs 0.0％ (0/28);control group:21.4％ (6/28) vs 0.0％ (0/28)] (P ＜ 0.05).At T1,MAP and SV in observation group were significantly higher than those in control group;the use rate of phenylephrine in observation group was significantly lower than that in control group (P ＜ 0.05).Conclusion Giving low doses of esmolol during general anesthesia induction contributes to stable SV and blood pressure in patient with hypertrophic obstructive cardiomyopathy.
Keywords：Cardiomyopathy,hypertrophicAnesthesia,generalEsmolol
Publication Date：2017-05-30
Online Publishing Date：2026-09-14(First online date of this platform, not the publication date of the document)
Pages：4( 660-663 )