Characteristics of ambulatory blood pressure in hypertensive patients with primary aldosteronism
Fan Wenbin
Yu Zhenqiu
Kuang Zemin
Ren Jingyuan
Yu Jing
Abstract：Objective To investigate characteristics of ambulatory blood pressure in hypertensive patients with primary aldosteronism(PA).Methods From January 2013 to December 2016,123 hypertensive patients with PA were included as observation group in Beijing Anzhen Hospital,Capital Medical University;124 patients with primary hypertension (PH) (sex,age and disease course matched) were included as control group.Blood pressure,blood pressure variability and circadian rhythm were analyzed.Results Comparisons between observation group and control group showed:① 24 h systolic blood pressure,daytime systolic blood pressure,nocturnal systolic blood pressure(nSBP),24 h diastolic blood pressure(24 hDBP),daytime diastolic blood pressure and nocturnal diastolic blood pressure (nDBP) in observation group were significantly higher than those in control group [(135±15)mmHgvs (127±15)mmHg,(137±14)mmHgvs (129±15)mmHg,(132±16)mmHgvs (122±17)mmHg,(86±11)mmHgvs (79±11)mmHg,(87±10)mmHg vs (81 ±11)mmHg,(81 ±10)mmHg vs (75 ± 12)mmHg] (P ＜0.01).②24 hDBP coefficient variation in observation group was significantly lower than that in control group[10.4(8.9,16.0) vs 10.6(9.7,13.0)] (P ＜0.05).③ the decline rate of nSBP in observation group was significantly lower than that in control group [3.6％ (0.0％,8.5％) vs 6.1％ (0.9％,10.0％)](P ＜ 0.05);the decline rate of nDBP had no significant difference between groups(P ＞ 0.05).④ 24 h heart rate (HR),daytime HR and nocturnal HR had no significant differences between groups (P ＞ 0.05).Comparisons among PA patients with different pathological types and lesion range showed:① 24 hDBP and nDBP in left side adenoma group and right side hyperplasia group were significantly lower than those in right side adenoma group [(85±10),(82±10)mmHgvs (90±12)mmHg;(81 ±10),(76±10)mmHgvs (86±9)mmHg](P＜0.05).② Parameters of blood pressure variability showed no siguificant differences among groups (P ＞ 0.05).③ Parameters of circadian rhythm showed no significant differences among groups (P ＞ 0.05).④ 24 h HR,daytime HR and nocturnal HR had no significant differences among groups (P ＞ 0.05).Conclusions There are differenees of ambulatory blood pressure parameters between hypertensive patients with PA and patients with PH.Pathological types and range of PA also have influences on ambulatory blood pressure.
Keywords：HypertensionPrimary aldosteronismAmbulatory blood pressureCircadian rhythm
Publication Date：2017-01-01
Online Publishing Date：2026-09-14(First online date of this platform, not the publication date of the document)
Pages：5( 655-659 )