Therapeutic effect of insulin detemir combined with liraglutide on obese type 2 diabetes
Qu Jianchang
Li li
Zhao Lei
Liang Yanling
Wang Tong
Zhu Kaisi
Abstract：Objective To analyze the therapeutic effect of insulin detemir combined with liraglutide on obese type 2 diabetes.Methods Thirty-two obese patients with type 2 diabetes were enrolled in the 305 Hospital of People's Liberation Army from November 2011 to September 2012.The patients were treated with insulin detemir and liraglutide for 24 weeks.Glycosylated hemoglobin(HbA1 c),fasting plasma glucose (FPG),postprandial 2 h plasma glucose(2hPG),total cholesterol (TC),triacylglycerol (TG),low density lipoprotein cholesterol (LDL-C),high density lipoprotein cholesterol and body mass were examined after 12,24 weeks of treatment.Blood glucose and body mass were examined every 2 weeks during treatment.Adverse reactions were recorded.Results Three cases withdrew from the observation (1 case had severe gastrointestinal reaction,1 case had frequent hypoglycemia,1 case had personal reasons).In 29 cases,hypoglycemia occurred in 12 cases and gastrointestinal reaction occurred in 17 cases.FPG,2hPG,HbA1c,TC,TG,LDL-C and body mass after 12,24 weeks of treatment were significantly lower than those before treatment [(7.1 ± 1.1),(6.8 ± 1.2) mmol/L vs (10.4±3.6)mmol/L;(9.5 ±1.9),(8.2±2.0)mmol/L vs (16.6 ±4.4)mmol/L;(7.5 ±0.7),(7.2± 0.6)％ vs (10.3 ±0.8)％;(4.5 ±0.9),(4.4 ±0.7) mmol/L vs (5.3 ± 1.0)mmoL/L;(1.8 ±0.8),(1.8 ± 0.6) mmol/L vs (2.1 ± 0.9) mmol/L;(3.1 ± 0.9),(3.1 ± 1.3) mmoL/L vs (3.6 ± 1.1) mmol/L;(94.4 ± 4.2),(91.2 ± 2.0) kg vs (103.2 ± 5.9) kg] (P ＜ 0.05);body mass after 24 weeks of treatment was significantly lower than that after 12 weeks of treatment (P ＜ 0.05).FPG,2hPG and body mass gradually decreased during treatment;FPG and 2hPG levels were stable after 8 weeks;body mass was stable after 20 weeks.Conclusion The treatment of insulin detemir in combination with liraglutide has obvious curative effect and weight-sparing effect on obese type 2 diabetes.
Keywords：Diabetes mellitus,type 2Insulin detemirLiraglutideObesity
Publication Date：2017-04-30
Online Publishing Date：2026-09-14(First online date of this platform, not the publication date of the document)
Pages：4( 542-545 )