Characteristics of coronary artery lesion, cardiac structure and function in acute coronary syndrome complicated with rheumatoid arthritis between different genders
Du Juan
Guo Yanqiu
Liao Hua
Pan Lili
Abstract：Objective To investigate characteristics of coronary artery lesion,cardiac structure and function in acute coronary syndrome(ACS) complicated with rheumatoid arthritis(RA) between different genders.Methods Fifty-two ACS patients complicated with RA were enrolled from April 2012 to January 2016 in Beijing Anzhen Hospital,Capital Medical University;62 ACS patients without RA (age and sex matched) were enrolled as a control group.General information,laboratory indexes,cardiovascular risk factors,SYNTAX score,echocardiogram parameters and serum level of brain natriuretic peptide (BNP) were analyzed.Results Serum level of highdensity lipoprotein cholesterol(HDL-C) in male RA group was significantly lower and high sensitivity C-reactive protein(hs-CRP) was higher than those in female RA group [(0.89 ± 0.20) mmol/L vs (0.99 ± 0.21) mmol/L;24.55 (5.08,33.57) mg/L vs 3.63 (1.60,17.94) mg/L] (P ＜ 0.05).Proportions of smoking and drinking in male RA group were significantly higher than those in female RA group[57.1％ (12/21) vs 12.9％ (4/31),19.0％ (4/21) vs 0.0％ (0/31)] (P ＜ 0.05).Left ventricular end-diastolic diameter(LVEDD),left ventricular endsystolic dimension(LVESD) and serum level of BNP in male RA group were significantly higher and left ventricular ejection fraction(LVEF) was lower than those in female RA group [(50 ± 8)mm vs (46 ± 4)mm,(37 ± 5)mm vs (30 ± 4) mm,208.35 (99.50,627.30) ng/L vs 172.00 (73.00,332.70) ng/L,(53 ± 3) ％ vs (61 ± 11) ％] (P ＜0.01 or P ＜0.05).LVEDD,LVESD and BNP in RA group were significantly higher and LVEF,mitral early diastolic peak flow velocity (E)/late diastolic peak flow velocity (A) were lower than those in control group [(48 ±6)mm vs (47 ±12)mm,(34 ±7)mm vs (33 ±6)mm,191.60(92.51,451.15)ng/L vs 176.52(85.77,398.60)ng/L,(55 ±9)％ vs (61 ± 17)％,0.72(0.64,1.17) vs 0.82(0.62,1.23)] (P ＜0.05).Conclusion Severity of coronary artery lesion in patients with ACS complicated with RA has no obvious difference between genders;damages on left ventricular function and cardiac structure in male are more severe.
Keywords：Acute coronary syndromeRheumatoid arthritisGenderCardiac function
Publication Date：2017-04-30
Online Publishing Date：2026-09-14(First online date of this platform, not the publication date of the document)
Pages：5( 491-495 )