Effect of pharmaceutical intervention based on systematic assessment of prescription on irrational use of antibiotics after cesarean section

Yang Songtao

doi:10.3760/cma.j.issn.1673-4777.2017.03.023

Abstract：Objective To investigate the effect of pharmaceutical intervention based on systematic assessment of prescription on antibiotics irrational use after cesarean section.Methods A total of 364 patients who had cesarean section from March 2013 to May 2016 in the First Hospital of China Medical University were divided into intervention group (n =188) and control group (n =176) according to order of admission.The control group had routine pharmaceutical instruction;the intervention group had pharmaceutical intervention based on systematic assessment of prescription.Rational use rates of antibiotics [including drug variety,drug combination,single dose,frequency of drug use,solvent],timing of drug administration,duration of drug use and medical expenses(including hospitalization expense,drug expense,antibiotics expense) were analyzed.Results Rational rates of drug variety,drug combination and frequency of drug use in intervention group were significantly higher than those in control group [92.6％ (174/188) vs 38.6％ (68/176),100.0％ (9/9) vs 37.9％ (11/29),94.7％ (178/188) vs 21.6％ (38/176)] (P ＜ 0.05).The rate of drug administrating before umbilical cord ligation in intervention group was significantly lower than that in control group [0.0％ (0/188) vs 6.8％ (12/176)] (P ＜ 0.05).The duration of postoperative drug use in intervention group was significantly shorter than that in control group [(2.5 ± 1.0) d vs (4.3 ± 1.3) d] (P ＜ 0.05).Expenses of hospitalization,drug and antibiotics in intervention group were significantly lower than those in control group [(4 419 ± 349) yuan vs (5 392 ±641)yuan,(838 ± 137)yuan vs (1 039 ± 181)yuan,(79 ±30)yuan vs (217 ±91)yuan] (P ＜0.05).Conclusion Pharmaceutical intervention based on systematic assessment of prescription can effectively improve rational use of antibiotics after cesarean section and reduce medical costs.