Clinical observation of Duhuo Jisheng decoction in treatment of knee osteoarthritis with deficiency of liver and kidney
Cao Hong
Zou Haibing
Zhang Lei
Zhang Jun
Abstract：Objective To analyze the clinical effect of Duhuo Jisheng decoction on knee osteoarthritis (KOA) with deficiency of liver and kidney.Methods A total of 42 patients with KOA from November 2013 to November 2015 in Renmin Hospital,Hubei University of Medicine were randomly divided into control group(n =20) and observation group (n =22).The control group took glucosamine hydrochloride capsule 0.75 g/time,2 times/d;the observation group had Duhuo Jisheng decoction for oral medication (1 dose/d,twice a day in morning and evening) and fumigation.Therapeutic effect was evaluated by Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC) and Visual Analogue Scale (VAS) after 12 weeks of treatment.The content of interleukin-1 (IL-1) in knee synovial fluid was determined by radioimmunoassay.Results WOMAC score,VAS score and IL-1 level had no significant differences between groups before treatment (P ＞ 0.05).WOMAC score,VAS score and IL-1 level were significantly decreased after treatment in both groups [control group:(34 ±7)scores vs (42 ±9) scores,(2.1 ± 1.3)scores vs (4.2 ± 1.7) scores,(386 ±40)ng/L vs (472 ± 47)ng/L;observation group:(26 ± 7) scores vs (42 ± 9) scores,(1.7 ± 1.1) scores vs (4.1 ± 1.9) scores,(316 ± 31) ng/L vs (469 ± 48) ng/L] (P ＜ 0.05).WOMAC score,VAS score and IL-1 level after treatment in observation group were significantly lower than those in control group (P ＜ 0.05).Conclusion Duhuo Jisheng decoction has good curative effect on knee osteoarthritis with deficiency of liver and kidney;it can alleviate symptoms and reduce level of IL-1 in synovial fluid.
Keywords：Osteoarthritis,kneeDuhuo Jisheng decoctionInterleukin-1
Publication Date：2017-03-30
Online Publishing Date：2026-09-14(First online date of this platform, not the publication date of the document)
Pages：4( 392-395 )