Observation of atorvastatin in combination with trepanation and drainage in treatment of chronic subdural hematoma with blood coagulation dysfunction
Wang Jiantao
Shi Lihai
Kan Zhisheng
Abstract：Objective To observe the curative effect of atorvastatin in combination with trepanation and drainage on chronic subdural hematoma(CSDH) with blood coagulation dysfunction.Methods A total of 186 cases of CSDH with blood coagulation dysfunction from January 2010 to June 2016 in Beijing Anzhen Hospital,Capital Medical University were retrospectively analyzed.The patients were divided into 2 groups;the control group(n =96) had conventional surgical treatment of trepanation and drainage;the observation group (n =90) had trepanation and drainage combined with atorvastatin.Clinical effect and hematoma relapse rate were analyzed.Results The total effective rate had no significant difference between observation group and control group [94.4％ (85/90) vs 92.7％ (89/96)](x2 =0.033,P ＞0.05).There were 3 cases(3.3％) of relapse in observation group and 12 cases (12.5％) of relapse in control group;the relapse rate in observation group was significantly lower than that in control group (x2 =4.101,P ＜ 0.05).Conclusion Trepanation and drainage in combination with atorvastatin treating CSDH with blood coagulation dysfunction can improve clinical effect and reduce hematoma relapse.
Keywords：Hematoma,subdural,chronicTrepanation and drainageAtorvastatinPostoperative recurrence
Publication Date：2017-03-30
Online Publishing Date：2026-09-14(First online date of this platform, not the publication date of the document)
Pages：5( 365-369 )