Clinical significance of cytological count and mycoplasma pneumoniae drug resistance gene in bronchoalveolar lavage fluid of refractory mycoplasma pneumoniae pneumonia in children
Chen Wei
Jia Lina
Guan Minchang
Hang Jinguo
Tang Weihong
Wang Guanfu
Abstract：Objective To explore the clinical significance of cytological count and mycoplasma pneumoniae (MP) drug resistance gene in bronchoalveolar lavage fluid (BALF) in children with refractory mycoplasma pneumoniae pneumonia(RMPP).Methods A retrospective analysis was performed in pediatric wards of 3 hospitals (Taizhou Hospital,Central Hospital,Luqiao hospital) affiliated to Taizhou Enze Medical Center (Group) in Zhejiang Province from April 2013 to April 2016;45 children diagnosed of RMPP(RMPP group) and 45 children diagnosed of mycoplasma pneumoniae pneumonia(MPP group) were enrolled;45 children who had bronchoscopy for removal of foreign body were enrolled as control group.All children had bronchoalveolar lavage and cytological count and MP drug resistance gene positive rate in BALF were analyzed.Results Nucleated cell count,macrophage ratio and neutrophil ratio in BALF had significant differences among RMPP group,MPP group and control group[1.7(0.8,2.6) × 109/L,1.6(0.7,2.4) × 109/L vs 0.8(0.4,1.4) × 109/L;85.1％ (71.5％,91.6％),86.5％ (79.8％,91.5％) vs 89.1％ (81.6％,97.0％);10.5％ (4.1％,18.3％),6.5％ (2.0％,14.0％) vs 2.6％ (1.4％,4.1％)] (P ＜ 0.01);lymphocyte ratio and eosinophil ratio had no differences among groups(P ＞0.05).The positive rate of MP drug resistant gene in RMPP group and MPP group was higher than that in control group[80.0％ (36/45),17.8％ (8/45) vs 0.0％ (0/45)];the positive rate of MP drug resistant gene in RMPP group was higher than that in MPP group;the differences were significant(P ＜ 0.01).Conclusion Neutrophil and MP drug resistance gene detection in BALF have certain reference values for early identification of RMPP in children.
Keywords：PneumoniamycoplasmaBronchoalveolar lavage fluidCell countResistance gene
Publication Date：2017-01-01
Online Publishing Date：2026-09-14(First online date of this platform, not the publication date of the document)
Pages：5( 351-355 )