Clinical significance of myocardial damage markers in neonatal infectious disease
Sun Na
Liu Guiying
Yang Xi
Su Ying
Abstract：Objective To analyze changes and clinical significance of myocardial damage markers in neonatal infectious disease.Methods A total of 213 neonates with infectious disease were enrolled in newborn ward of Beijing Anzhen hospital,Capital Medical University from January 2015 to June 2016,including 165 cases of neonatal pneumonia (pneumonia group),48 cases of septicemia (septicemia group),121 cases of natural childbirth(natural childbirth group),92 cases of cesarean section (cesarean section group).Serum levels of aspartate aminotransferase(AST),creatine kinase (CK),creatine kinase isoenzyme (CK-MB),lactate dehydrogenase(LDH) and troponin Ⅰ(cTnI) before and after 7 d of treatment were analyzed.Results Ratios of neonates with high serum levels of AST,CK,CK-MB,LDH,cTnI were 208 (97.7％),90 (42.3％),206 (96.7％),187(87.8％),51 (23.9％),respectively.Serum levels of AST,CK-MB and LDH in septicemia group were significantly higher than those in pneumonia group [(93 ± 11) U/L vs (67 ± 4) U/L,(39.5 ± 5.3) μg/L vs (28.3 ± 1.9) μg/L,(701 ± 39) U/L vs (607 ± 19) U/L] (P ＜ 0.01 or P ＜ 0.05);CK and cTnI had no significant differences between groups(P ＞0.05).The serum level of LDH in cesarean section group was significantly lower than that in natural childbirth group [(581 ± 25) U/L vs (670 ± 33) U/L] (P ＜ 0.05);AST,CK,CK-MB and cTnI had no significant differences between groups (P ＞ 0.05).Serum levels of AST,CK,CK-MB and LDH in 112 neonates after 7 d of treatment were significantly lower than those before treatment [(39.6 ± 2.3)U/L vs (78.7 ±4.7)U/L,(388 ±41)U/L vs (1 311 ±99) U/L,(15.1 ±2.5) μg/L vs (38.6 ±2.8) μg/L,(425 ± 15) U/L vs (671 ± 26) U/L] (P ＜ 0.01);cTnI there had no significant difference before and after treatment(P ＞ 0.05).Conclusion Neonatal infection can cause increased levels of myocardial damage markers,which is associated with severity of infection.
Keywords：Infectious diseaseInfant,newbornMyocardial enzymeTroponin Ⅰ
Publication Date：2017-03-30
Online Publishing Date：2026-09-14(First online date of this platform, not the publication date of the document)
Pages：4( 335-338 )