Effects of different loading doses of tirofiban on myocardial injury and artery blood flow in patients with acute ST-elevation myocardial infarction after percutaneous coronary intervention
Liu Hai
Ren Yong
Ding Xinghua
Tang Yongqian
Abstract：Objective To explore the effects of different loading doses of tirofiban on myocardial injury and artery blood flow in patients with acute ST-elevation myocardial infarction(STEMI) after percutaneous coronary intervention (PCI).Methods Totally 180 patients with acute STEMI after PCI from March 2013 to March 2015 in Xiangyang Central Hospital,Hubei Province were enrolled and randomly divided into control group(90 cases) and observation group(90 cases).The control group had single loading dose of tirofiban and the observation group had double loading doses of tirofiban before PCI.Creatine kinase isoenzyme-MB (CK-MB) and cardiac troponin Ⅰ (cTnⅠ) were tested before and 6,18,24 h after PCI.Thrombolysis in myocardial infarction(TIMI) flow classification and myocardial perfusion classification were measured after PCI.Major adverse cardiovascular events (MACE),hemorrhage and thrombocytopenia were recorded.Results Levels of CK-MB and cTnⅠ 6,18,24 h after PCI were significantly higher than those before PCI in both groups[control group:(170 ± 23),(244 ± 121),(125 ±47)U/L vs (65 ±62)U/L;(4.13 ± 1.25),(9.47 ±2.47),(3.85 ± 1.36) μg/L vs (0.13 ± 0.04) μg/L;observation group:(139 ± 38),(179 ± 93),(91 ± 40) U/L vs (65 ± 62) U/L;(2.07 ± 0.45),(4.48 ± 1.43),(3.18 ± 1.09) μg/L vs (0.12 ± 0.04) μg/L] (P ＜ 0.05).Levels of CK-MB and cTnⅠ in observation group were significantly lower than those in control group 6,18,24 h after PCI(P ＜0.05).Grade 3 rates of TIMI flow and myocardial perfusion in observation group were significantly higher than those in control group[91.1％ (82/90) vs 74.4％ (67/90);88.9％ (80/90) vs 75.6％ (68/90)] (P ＜ 0.05).Incidence of MACE in observation group was significantly lower than that in control group [5.6％ (5/90) vs 15.6％ (14/90)] (P ＜ 0.05);incidences of hemorrage and thrombocytopenia showed no significant differences between groups (P ＞ 0.05).Conclusion Double loading doses of tirofiban for patients with acute STEMI can alleviate myocardial injury,improve artery blood flow and decrease risk of MACE after PCI without increasing risk of bleeding.
Keywords：ST-segment elevation myocardial infarctionPercutaneous coronary interventionTirofibanMyocardial injuryArtery blood flow
Publication Date：2017-02-28
Online Publishing Date：2026-09-14(First online date of this platform, not the publication date of the document)
Pages：5( 191-195 )