Clinical significances of interleukin-1 and interleukin-6 in serum and tumor tissue in early gastric cancer

Zhao Tao; Chen Hua; Wu Wenfeng

doi:10.3760/cma.j.issn.1673-4777.2017.01.020

Abstract：Objective To analyze the clinical significances of interleukin-1 (IL-1) and IL-6 in serum and tumor tissue in early gastric cancer patients.Methods From January 2014 to January 2015 in Chengdu Military General Hospital,40 cases of early gastric cancer(gastric cancer group) and 20 cases of gastric ulcer(gastric ulcer group) were enrolled;20 healthy people were selected as control group.Levels of IL-1,IL-6 in blood,gastric cancer tissue,adjacent tissue and gastric mucosa tissue were detected by enzyme linked immunosorbent assay.Relation between interleukin level and clinical pathological characteristics was analyzed.Results Serum levels of IL-1,IL-6 in gastric cancer group were significantly higher than those in gastric ulcer group and control group [IL-1:(1.451 ±0.032) μg/L vs (1.090 ±0.024),(0.030 ± 0.010) μg/L;IL-6:(1.593 ± 0.084) μg/L vs (1.076 ± 0.029),(0.027 ± 0.011) μg/L];IL-1,IL-6 in gastric ulcer group were significantly higher than those in control group(all P＜0.05).In gastric cancer group,positive expression rates of IL-1 and IL-6 were 80.0％ (32/40) and 75.0％ (30/40),which were significantly higher than those in gastric ulcer group [30.0％ (6/20) and 20.0％ (4/20)] (P ＜0.05).Levels of IL-1 and IL-6 were related to differentiation degree,clinical stage,invasion depth and lymph node metastasis of gantric cancer (P ＜ 0.05).Conclusion IL-1 and IL-6 are highly expressed in serum and cancer tissue in patients with early gastric cancer;levels of IL-1 and IL-6 are related to differentiation degree,clinical stage,invasion depth and lymph node metastasis.