Efficacy analysis of transcatheter arterial chemoembolization in combination with 125I seed implantation in the treatment of primary liver cancer
Yu Xiongjie
Li Yanli
Lei Jinhua
Di Quanshu
Li Xinhui
Cao Fengjun
Abstract：Objective To analyze the efficacy of transcatheter arterial chemoembolization (TACE in combination with 125I seed implantation in the treatment of primary liver cancer.Methods A total of 94 cases of primary liver cancer from March 2010 to February 2013 in Renmin Hospital,Hubei University of Medicine were divided into observation group and control group,with 47 cases in each group.The control group had TACE;the observation group had TACE in combination with 125I seed implantation.Serum alpha-fetoprotein (AFP) level,short-term efficacy,adverse reaction incidence and survival rate were analyzed.Results The negative conversion rate and total reduction rate of AFP in observation group(22 patients with positive AFP) were significantly higher than those in control group(21 patients with positive AFP) 1 month after treatment[59.1％ (13/22) vs 28.6％ (6/21),x2 =5.82,P =0.01;95.5％ (21/22) vs 81.0％ (17/21),x2 =3.86,P =0.04].The total effective rate in observation group was significantly higher than that in control group 2 months after treatment [85.1％ (40/47) vs 68.1％ (32/47),x2 =5.59,P =0.01].The adverse reaction incidence had no significant difference between groups(P ＞ 0.05).The 1-,2-,3-year survival rates in observation group were significantly higher than those in control group [93.6 ％ (44/47) vs 80.9 ％ (38/47),x2 =4.71,P =0.03;78.7 ％ (37/47) vs 53.2％ (25/47),x2 =6.82,P＜0.01;55.3％(26/47) vs34.0％(16/47),x2 =6.15,P=0.01].Conclusion TACE in combination with 125I seed implantation can increase short-term efficacy,reduce AFP level and improve survival rate in patients with primary liver cancer.
Keywords：Primary liver cancerTranscatheter hepatic arterial chemoembolization125I seed implantation
Publication Date：2017-01-01
Online Publishing Date：2026-09-14(First online date of this platform, not the publication date of the document)
Pages：5( 77-81 )