Clinical effect of Xingnaojing injection combined with hyperbaric oxygen on carbon monoxide poisoning

Jiang Baozhou; Ai Wenting; Liu Danping

doi:10.3760/cma.j.issn.1673-4777.2017.01.014

Abstract：Objective To explore the clinical effect of Xingnaojing injection combined with hyperbaric oxygen therapy in treating carbon monoxide(CO) poisoning.Methods Totally 80 cases of CO poisoning from October 2011 to October 2013 in Shaanxi Provincial People's Hospital were randomly divided into observation group and control group,with 40 cases in each group.The control group was treated with hyperbaric oxygen therapy;the observation group was treated with Xingnaojing injection(20 ml,mixed with 5％ glucose injection,intravenous drip,1 time/d) combined with hyperbaric oxygen therapy.Both groups were treated for 15 d and they were followed up for 3 months after treatment.The degree of coma was evaluated by Glasgow Coma Scale (GCS) before treatment and 24 h after treatment.Clinical effect and the occurrence of delayed encephalopathy were analyzed between groups.Results The total effective rate in observation group was significantly higher than that in control group [97.5％ (39/40) vs 80.0％ (32/40)] (P ＜ 0.05).After treatment,GCS scores were significantly higher than those before treatment in both groups [observation group:(14.9 ± 1.8) scores vs (4.2 ± 1.6) scores,control group:(10.6 ± 1.7) scores vs (4.4 ± 1.3) scores] (P ＜ 0.05),and the GCS score in observation group was significantly higher than that in control group (P ＜ 0.05).The incidence of delayed encephalopathy in observation group was significantly lower than that in control group [2.5 ％ (1/40) vs 15.0％ (6/40)] (P ＜ 0.05).Conclusion Xingnaojing injection combined with hyperbaric oxygen therapy is effective in the treatment of CO poisoning;it can significantly reduce coma symptom and the incidence of delayed encephalopathy.