Effect of Shuxuening on heart-type fatty acid binding protein and inflammatory factors in severe sepsis patients with myocardial depression
Qi Hongna
Zhang Jianjun
He Jiaqi
Wang Weizhan
Li Yaqin
Abstract：Objective To investigate the effects of Shuxuening on heart-type fatty acid binding protein (H-FABP),tumor necrosis factor-a(TNF-a) and interleukin-6 (IL-6) in severe sepsis patients with myocardial depression.Methods Totally 86 severe sepsis patients with myocardial depression from January 2013 to April 2016 in Harrison International Peace Hospital were randomly divided into control group and observation group,with 43 cases in each group.The control group was treated with routine treatment;the observation group was treated with Shuxuening injection 20 ml added into 0.9％ sodium chloride injection 250 ml,1 time/d intravenous injection for 14 d.Serum levels of H-FABP,cardiac troponin I (cTnI),TNF-α and IL-6 were detected before and 6 h,3 d after treatment.Acute Physiology and Chronic Health Evaluation (APACHE) Ⅱ score and cumulative incidence of major adverse cardiac events (MACE) were analyzed.Results Before treatment,there were no significant differences of H-FABP,cTnI,TNF-α,IL-6 and APACHE Ⅱ score between groups [(24.5 ± 7.0)μg/L vs (25.1 ±6.6)μg/L,(0.004 1 ±0.003 2) μg/L vs (0.003 2 ±0.002 3) μg/L,(26 ±7)ng/L vs (26 ± 6) ng/L,(40 ± 8) ng/L vs (40 ± 9) ng/L,(24 ± 7) scores vs (24 ± 6) scores] (P ＞ 0.05).After 6 h of treatment,H-FABP,cTnI,TNF-α,IL-6 and APACHE Ⅱ scores were significantly higher than those before treatment in both groups;these indexes in observation group were significantly lower than those in control group [(35.4 ±8.1) μg/L vs (40.6 ± 10.2) μg/L,(0.982 3 ±0.143 5) μg/L vs (1.594 6 ±0.261 7) μg/L,(34 ± 9) ng/L vs (39 ± 9) ng/L,(42 ± 7) ng/L vs (46 ± 8) ng/L,(17 ± 5) scores vs (20 ± 6) scores] (all P ＜ 0.05).After 3 d of treatment,H-FABP,TNF-α,IL-6 and APACHE Ⅱ scores were significantly lower those after 6 h of treatment;cTnI was significantly higher than that after 6 h of treatment;levels of TNF-α,IL-6,APACHE Ⅱ score and cTnI in observation group were significantly lower than those in control group [(2.057 6 ± 0.326 2) μg/L vs (2.682 9 ±0.543 4) μg/L,(21 ±6)ng/L vs (25 ±5)ng/L,(30 ± 6) ng/L vs (35 ±7) ng/L,(11 ±4) scores vs (15 ± 4) scores] (all P ＜ 0.05);H-FABP had no significant difference between groups (P ＞ 0.05).The observation group had a lower cumulative incidence of MACE compared to control group and the difference was significant [7.0％ (3/43) vs 23.3％ (10/43)] (x2 =4.440,P =0.035).Conclusion Shuxuening can reduce tissue hypoxia,decrease TNF-α,IL-6 levels and lessen inflammatory reaction;it is effective in the treatment of patients with severe sepsis and myocardial depression.
Keywords：SepsisMyocardial depressionHeart-type fatty acid binding proteinShuxueningTumor necrosis factor-αInterleukin-6
Publication Date：2017-01-01
Online Publishing Date：2026-09-14(First online date of this platform, not the publication date of the document)
Pages：5( 36-40 )