Effect of obesity and overweight on left ventricular structure and function in patients with coronary atherosclerotic heart disease
Chen Xuanzu
Luo Taiyang
Dai Tianyi
Li Zhizhong
Zhang Zichuang
Abstract：Objective To investigate the effect of obesity and overweight on left ventricular structure and function in patients with coronary atherosclerotic heart disease(CHD).Methods Totally 367 patients diagnosed of CHD (at least 1 coronary artery stenosis ≥ 50％) from September 2014 to March 2015 in Beijing Anzhen Hospital,Capital Medical University were enrolled.The patients were divided into 3 groups according to body mass index(BMI):normal weight group (BMI ＜ 24.0 kg/m2,77 cases),overweight group (BMI 24.0-27.9 kg/m2,178 cases),obesity group(BMI ≥28 kg/m2,112 cases).Height,body mass,waistline and hipline were measured;high sensitive C-reactive protein (hs-CRP),interleukin-6 (IL-6),tumor necrosis factor-α (TNF-α) were tested;left venticular end-diastolic diameter(LVEDD),left venticular end-systolic diameter(LVESD),left atrial diameter(LAD),left venticular ejection fraction(LVEF),mitral peak early flow velocity(E) and peak late flow velocity (A) were determined.The correlation between BMI and left venticular indexes was analyzed.Results The E value in overweight group was significantly higher than that in normal weight group [(73 ± 20)mm/s vs (68 ± 19) mm/s] (P ＜0.05),LVEDD and E value in obesity group were significantly higher than those in normal weight group and overweight group [(50 ± 5) mm vs (48 ± 7),(48 ± 5) mm;(78 ± 20) mm/s vs (68 ± 19),(73 ± 20) mm/s] (P ＜ 0.05).The hs-CRP level in overweight group and obesity group were significantly higher than those in normal weight group (P ＜ 0.05).BMI was positively correlated with LVEDD,LVESD,LAD,hs-CRP,IL-6 and TNF-α (all P ＜ 0.05).Multivariate linear regression showed that BMI was correlated with LVEDD (β =0.127,P =0.022).Conclusion CHD patients with obesity are associated with large left venticular diameter and bad diastolic function;the mechanism may be related to inflammatory response.
Keywords：Coronary atherosclerotic heart diseaseObesityOverweight
Publication Date：2017-01-30
Online Publishing Date：2026-09-14(First online date of this platform, not the publication date of the document)
Pages：4( 33-36 )