Efficacy and safety of carvedilol combined with nicorandil in treating coronary atherosclerotic heart disease with myocardial ischemia and left ventricular diastolic dysfunction
Lei Rui
Yin Shi
Liu Hongling
Li Zhi
Abstract：Objective To analyze the efficacy and safety of carvedilol combined with nicorandil in the treatment of coronary atherosclerotic heart disease with myocardial ischemia and left ventricular diastolic dysfunction.Methods Totally 118 cases of coronary atherosclerotic heart disease with myocardial ischemia complicated with left ventricular diastolic dysfunction from January 2013 to January 2015 in Jiamusi Central Hospital were randomly divided into observation group and control group,with 59 cases in each group.The control group was treated with routine therapy with isosorbide dinitrate,simvastatin and aspirin;the observation group was added carvedilol and nicorandil for 12 weeks.Clinical effect,heart color Doppler ultrasound parameters,ST-segment depression frequency and duration were analyzed.Results The total effective rate in observation group was significantly higher than that in control group [89.8％ (53/59) vs 55.9％ (33/59)] (P ＜ 0.05).Inter-ventricular septum end-diastolic,left ventricular posterior wall end-diastolic,mitral A peak,ST-segment depression frequency and duration were significantly lower and mitral E peak,E/A ratio were significantly higher in observation group than those in control group after treatment [(8.0 ± 0.5)mm vs (9.5 ± 0.5) mm,(8.0 ± 0.3)mm vs (9.4 ±0.6) mm,(59 ± 10) cm/s vs (69 ± 14) cm/s,(2.0 ± 1.1) times/24 h vs (3.6 ± 1.3) times/24 h,(15±4)minvs (27±10)min,(70±12)cm/s vs (60±11)cm/s,(1.17±0.41) vs (0.87±0.28)](P＜ 0.05).There was no significant difference of adverse drug reaction incidence between groups (P ＞ 0.05).Conclusion Carvedilol combined with nicorandil treating coronary atherosclerotic heart disease myocardial ischemia complicated with left ventricular diastolic dysfunction is safe and effective.
Keywords：Coronary artery diseaseCarvedilolNicorandilMyocardial ischemiaLeft ventricular diastolic dysfunction
Publication Date：2017-01-30
Online Publishing Date：2026-09-14(First online date of this platform, not the publication date of the document)
Pages：5( 19-23 )