Effect of palonosetron plus dexamethasone on the prevention of postoperative nausea and vomiting after gynecological laparoscopic operation
Hao Shuai
Wu Jia
Luo Chao
Quan Zhefeng
Yang Bei
Chi Ping
Abstract：Objective To observe the effect of palonosetron plus dexamethasone on the prevention of postoperative nausea and vomiting (PONY) after gynecological laparoscopic operation.Methods Totally 80 patients scheduled gynecological laparoscopic operation from May 2015 to February 2016 in Beijing YouAn Hospital,Capital Medical University were randomly divided into palonosetron group and palonosetron plus dexamethasone group,with 40 cases in each group.The palonosetron group was administered palonosetron 0.075 mg(4 ml) and the palonosetron plus dexamethasone group was administered palonosetron 0.075 mg(4 ml)and dexamethasone 8 mg (4 ml) before anesthesia induction.Nausea and vomiting incidence and severity,compensational drug use rate and adverse reaction rate were recorded at 0-6 h,＞ 6-24 h,＞ 24-48 h after operation.Results Incidences of nausea and vomiting in palonosetron plus dexamethasone group at ＞ 6-24 h after operation were significantly lower than those in palonosetron group[15.0％ (6/40) vs 30.0％ (12/40),7.5％(3/40) vs 22.5 ％ (9/40)] (P ＜ 0.05).Nausea and vomiting severity,compensational drug use rate and adverse reaction rate had no significant differences between groups (P ＞ 0.05).Conclusion Palonosetron 0.075 mg plus dexamethasone 8 mg is more effective in the prevention of PONV after gynecological laparoscopic operation compared to palonosetron 0.075 mg alone,without increasing side effects.
Keywords：Gynecologic laparoscopic surgical proceduresLaparoscopesPalonosetronDexamethasonePostoperative nausea and vomiting
Publication Date：2016-01-01
Online Publishing Date：2026-09-14(First online date of this platform, not the publication date of the document)
Pages：5( 1828-1832 )