Correlation between smoking and serum direct bilirubin level in male patients with coronary atherosclerotic heart disease
Zhang Yanyan
He Jianxun
Zhao Song
Yuan Hui
Wang Aiping
Li Zhizhong
Wang Su
Abstract：Objective To analyze the correlation between smoking and serum direct bilirubin level in male patients with coronary atherosclerotic heart disease(CHD).Methods Totally 1 560 male patients with CHD from January 2009 to December 2012 in Beijing Anzhen Hospital,Capital Medical University were divided into 2 groups according to the median serum direct bilirubin level [2.890(0.010,9.960)μmol/L]:observation group (780 cases,serum direct bilirubin ≤ 2.890 μmol/L) and control group (780 cases,serum direct bilirubin ＞2.890.μmol/L).Age,body mass index,smoking,alcoho-drinking,hypertension history,diabetes history,acute myocardial infarction history,hemoglobin(Hb),white blood cell count(WBC),alanine aminotransferase(ALT),creatinine (Cr),uric acid (UC),total cholesterol (TC),triacylglycerol(TG),high-density lipoprotein cholesterol (HDL-C) and low-density lipoprotein cholesterol (LDL-C) were analyzed.Results Age,Hb,Cr,UC and HDL-C in observation group were significantly lower than those in control group;smoking ratio,drinking ratio,TC,TG and LDL-C were significantly higher than those in control group [55 (32,80) years vs 57 (24,83) years,146(120,198) g/L vs 148 (120,187) g/L,81.0 (24.0,186.9) μmol/L vs 82.0 (45.0,197.0) μmol/L,348 (152,852) μmol/L vs 362 (132,741) μ mol/L,0.9 (0.4,2.1) mmol/L vs 0.9 (0.5,2.3) mmoL/L,68.7％ (536/780) vs 56.5％ (441/780),26.7％ (208/780) vs 21.7％ (169/780),4.3 (2.0,10.9) mmol/L vs4.0(2.1,9.1)mmol/L,1.74(0.27,16.71)mmol/L vs 1.45(0.05,18.29)mmol/L,2.7(1.0,8.5) mmol/L vs 2.5 (0.8,5.4) mmol/L] (P ＜ 0.05).Spearman rank correlation analysis showed a negative correlation between smoking and serum direct bilirubin level (r =-0.175,P ＜ 0.001).Multivariate logistic regression analysis revealed that smoking was an independent influence factor of serum direct bilirubin level (odds ratio =1.468,95％ confidence interval:1.170-1.842,P =0.001).Conclusion Smoking is correlated with low serum direct bilirubin level in male patients with CHD.
Keywords：Coronary artery diseaseAtherosclerosisSmokingDirect bilirubin
Publication Date：2016-01-01
Online Publishing Date：2026-09-14(First online date of this platform, not the publication date of the document)
Pages：4( 1766-1769 )