Effect of trimetazidine on myocardial injury and recurrence angina pectoris after percutaneous coronary intervention in unstable angina pectoris patients with diabetes
Dai Wenli
Wu Xiangyu
Li Zhao
Wang Su
Li Zhizhong
Abstract：Objective To evaluate the effect of trimetazidine on myocardial injury and recurrence angina pectoris in unstable angina pectoris (UAP) patients with diabetes after percutaneous coronary intervention(PCI).Methods A totally of 192 UAP patients with diabetes undergoing PCI were divided into trimetazidine group and conventional treatment group according to the random number table method,with 96 cases in each group.The conventional treatment group was treated with routine treatment;the trimetazidine group had trimetazidine 20 mg/time,3 times/d before PCI and maintain the same dose after PCI for 6 months.The level of serum cardiac troponin Ⅰ(cTnⅠ) was tested before PCI and at 16,24 h after PCI.Recurrent angina pectoris was observed through 6 months of telephone follow-up;echocardiography was reexamined at 6 months after PCI and left ventricular ejection fraction(LVEF) was determined.Results The cTnⅠ levels were gradually increased after PCI in both groups,the increasing range in trimetazidine group was smaller than that in conventional treatment group;cTnⅠ levels at 16,24 h after PCI had significant differences between groups[(0.15 ± 0.05) μg/L vs (0.45 ± 0.20) μg/L,(0.22 ± 0.11) μg/L vs (0.67 ± 0.11) μg/L] (P ＜ 0.01).The recurrent angina pectoris rate during 6 months after PCI in trimetazidine group was lower than that in conventional treatment group[8.3％ (8/96) vs 22.9％ (21/96)];the LVEF at 6 months after PCI in trimetazidine group was higher than that in conventional treatment group[(56.1 ±2.2)％ vs (50.8 ±2.4)％],the differences were statistically significant (P ＜ 0.05).Conclusion Trimetazidine can ameliorate PCI-induced myocardial injury,reduce the incidence of recurrent angina pectoris and improve left ventricular function.
Keywords：Angina,unstableDiabetes mellitusTrimetazidineCardiac troponin IPercutaneous coronary intervention
Publication Date：2016-12-30
Online Publishing Date：2026-09-14(First online date of this platform, not the publication date of the document)
Pages：4( 1753-1756 )