Correlation between platelet morphology and SYNTAX score in patients with acute coronary syndrome complicated with diabetic nephropathy
Liu Lianfeng
Zhou Yujie
Liu Yuyang
Abstract：Objective To explore the correlation between platelet morphological indexes and coronary SYNTAX score in patients with acute coronary syndrome (ACS) complicated with diabetic nephropathy (DN).Methods Totally 190 patients diagnosed of ACS with DN from January 2012 to December 2015 in Beijing Anzhen Hospital,Capital Medical University were enrolled.All patients had platelet morphological indexes test[including mean platelet volume (MPV),platelet distribution width (PDW),platelet-large cell rate (P-LCR)] and coronary angiography examination.The SYNTAX score was calculated according to the result of coronary angiography;all patients were divided into low-score group(SYNTAX≤22 scores),mid-score group(SYNTAX 23-32 scores) and high-score group (SYNTAX ≥ 33 scores).Correlations of SYNTAX score with MPV,PDW and P-LCR were analyzed.Results There were respectively 101,50,39 cases in low-,mid-,high-score groups.MPV,PDW and P-LCR levels in high-score group were significantly higher than those in mid-,low-score groups [(12.6 ± 0.8)fL vs (11.6±0.6),(10.7±0.8)fL;(17.4 ±2.4)％ vs (14.6±1.6)％,(12.8 ±1.7)％;(45 ±6)％ vs (38±5) ％,(31 ± 7) ％] (P ＜ 0.05).Multivariate Logistic regression analysis showed that platelet morphological index was a risk factor of high SYNTAX score (odds ratio =6.154,95％ confidence interval:3.260-11.618,P =0.001).Spearman correlation analysis showed that MPV(r =0.723,P ＜ 0.001),PDW(r =0.708,P ＜ 0.001)and P-LCR(r =0.727,P ＜0.001) were positively correlated with SYNTAX score.Multinomial linear regression analysis showed that platelet morphological index(standardized coefficient:0.799,P ＜ 0.001) and urea(standardized coefficient:0.136,P =0.016) were independent influence factors of SYNTAX score.Conclusion Platelet morphological index is positively correlated with the severity of coronary lesion.
Keywords：Acute coronary syndromeDiabetic nephropathiesMean platelet volume
Publication Date：2016-12-30
Online Publishing Date：2026-09-14(First online date of this platform, not the publication date of the document)
Pages：5( 1745-1749 )