Clinical value of microalbuminuria and blood-renal function indexes in children with nephrotic syndrome
Abstract：Objective To investigate the clinical value of microalbuminuria and blood-renal function indexes in children with nephrotic syndrome (NS).Methods One hundred and fourteen children with NS from January to December 2014 in Shandong Provincial Hospital Affiliated to Shandong University were enrolled as observation group which was divided into normal microalbuminuria group(52 cases) and abnormal microalbuminuria group (62 cases) according to the detection after treatment.Thirty healthy children with similar ages were selected as control group.Urine protein,microalbuminuria,urine immunoglobulin(Ig) G and blood-renal function indexes [albumin (ALB),blood urea nitrogen (BUN),serum creatinine (SCr),cystatin C (CysC),β2-microglobulin (β2-MG),retinol binding protein(RBP),complement C1q] were analyzed.Results ①In observation group,urine protein positive rate was 31.6％ (36/114) and microalbuminuria positive rate was 54.4％ (62/114);the difference was statistically significant(P ＜ 0.05).②In normal microalbuminuria group,β2-MG,BUN,RBP were significantly lower than those in control group;urine IgG,BUN/SCr and C1q were significantly higher than those in control group[(1.48 ± 0.24) mg/L vs (1.84 ± 0.47) mg/L,(4.4 ± 1.5) mmol/L vs (4.6 ± 0.8) mmol/L,(29 ± 10)mg/L vs (33 ±7)mg/L,(4.4 ±3.3) mg/L vs (4.0 ±0.6)rmg/L,(122 ±65) vs (60 ± 10),(180 ± 22) mg/L vs (176 ± 13) mg/L] (P ＜ 0.01 or P ＜ 0.05);ALB,SCr,CysC showed no significant differences between groups(P ＞0.05).In abnormal microalbuminuria group,urine IgG,BUN,BUN/SCr,CysC,RBP and C1q were significantly higher than those in control group;ALB was significantly lower than those in control group [(28.7 ± 44.3) mg/L vs (4.0 ± 0.6) mg/L,(5.0 ± 1.9) mmol/L vs (4.6 ± 0.8) mmol/L,(129 ± 43) vs (60 ± 10),(0.98 ±0.24) mg/L vs (0.81 ± 0.14) mg/L,(35 ± 12) mg/L vs (33 ± 7) mg/L,(184 ± 25) mg/L vs (176 ± 13)mg/L,(36.6 ±8.1)g/L vs (45.6 ±2.0)g/L] (P ＜0.01 or P ＜0.05);SCr,β2-MG showed no significant differences between groups (P ＞ 0.05).③In normal mieroalbuminuria group,microalbuminuria was correlated with SCr and BUN/SCr (r =0.35,0.32;all P ＜ 0.05).In abnormal microalbuminuria group,microalbuminuria was correlated with urine IgG,ALB,RBP and C1q(r =0.92,0.61,0.25,0.30;all P ＜ 0.05).Conclusions Mieroalbuminuria can evaluate the curative effect in NS children.For children with normal microalbuminuria after treatment,combination of microalbuminuria and blood-renal function indexes can help clinical judgments.
Keywords：Nephrotic syndromeChildrenMicroalbuminuria
Publication Date：2016-11-30
Online Publishing Date：2026-09-14(First online date of this platform, not the publication date of the document)
Pages：5( 1662-1666 )