Serum concentration analysis of oxcarbazepine active metabolite in children with epilepsy
Ma Jing
Huang Xiaohui
Chen Jihui
Qi Jia
Zhang Chun
Liu Yan
Xu Ajing
Abstract：Objective To analyze the serum concentration of monohydroxycarbazepine(MHD),the active metabolite of oxcarbazepine,in children with epilepsy.Methods Totally 987 epileptic children who were treated with oxcarbazepine from October 2013 to December 2015 in Xin Hua Hospital Affiliated to Shanghai Jiao Tong University School of Medicine were enrolled.After 3-5 d of treatment,fasting blood was sampled and serum concentration of MHD was detected by high performance liquid chromatography (HPLC) method.Results The therapeutic window of MHD was set as 15-35 mg/L;detection results showed that 54.0％ (533/987) in 987 cases were in this range,45.8％ (452/987) targets were on the low side and 0.2％ (2/987) targets were on the high side.The serum concentration of MHD increased with age[0-5 years old:(14.27 ±0.32)mg/L,6-14 years old:(16.28 ± 0.22) mg/L,15-18 years old:(16.46 ± 1.00) mg/L,F =1.69,P ＜ 0.05];but it had no significant difference between genders (P =0.63).Conclusions In the treatment of epilepsy with oxcarbazepine in children,the serum concentration of MHD varies individually.MHD serum concentration increases with age.
Keywords：EpilepsyOxcarbazepineActive metaboliteSerum concentrationChildren
Publication Date：2016-11-30
Online Publishing Date：2026-09-14(First online date of this platform, not the publication date of the document)
Pages：3( 1634-1636 )