Clinical characteristics of cognitive impairment in patients with asymptomatic carotid artery stenosis
Zhang Hua
Zhang Shuping
Wang Xiaoxin
Abstract：Objective To analysis clinical characteristics of cognitive impairment in patients with asymptomatic carotid artery stenosis.Methods Forty-two patients with asymptomatic carotid artery stenosis from January to October 2015 in Beijing Anzhen Hospital,Capital Medical University were enrolled as stenosis group,which was subdivided into mild-moderate stenosis group (30％-69％ stenosis) and severe stenosis group (70％-99％ stenosis) according to the diagnostic standard of North American symptomatic carotid endarterectomy trial.Forty patients without carotid stenosis were selected as control group.Mini-mental state examination (MMSE) score,event related potentials(ERP)-P300 latency and amplitude were analyzed to evaluate the cognitive function.The correlation between cognitive function and carotid stenosis degree was analyzed.Results ERP-P300 latencies in mild-moderate and severe stenosis groups were significantly longer [(377 ± 32),(385 ± 43) ms vs (344 ± 38) ms] (P ＜ 0.05) and the MMSE score in severe stenosis group was significant lower[(25.6 ± 1.7) socres vs (27.5 ± 2.4) scores] (P ＜ 0.05) compared to those in control group.Correlation analysis showed positive correlation between ERP-P300 latency and carotid stenosis degree(F =2.237,P =0.032).Conclusions Patients with carotid stenosis have cognitive impairment.Prolonged ERP-P300 latency is a sensitive diagnostic factor of cognitive impairment.
Keywords：Carotid artery stenosisCognitive impairmentEvent related potentials-P300Mini-mental state examination
Publication Date：2016-01-01
Online Publishing Date：2026-09-14(First online date of this platform, not the publication date of the document)
Pages：5( 1625-1629 )