Effect of ulinastatin on inflammatory factors in treating severe acute pancreatitis and its clinical significance analysis
Chen Ningbo
Zeng Jie
Abstract：Objective To explore effect of ulinastatin (UTI) on inflammatory factors in treating severe acute pancreatitis (SAP) and analyze the clinical significance.Methods Totally 80 SAP patients from January 2010 to January 2013 were randomly divided into UTI group and control group (40 cases in each group).All the patients received routine treatment,including fasting,gastrointestinal decompression,inhibition of pancreatic secretion,anti-infection and intravenous nutrition,while patients in UTI group additionally received intravenous drip of UTI 200 000 U (1 time/8 h),the treatment lasted for 7 days.Blood samples were taken to measure the levels of serum procalcitonin (PCT),interleukin 6 (IL-6),IL-8,IL-10 on admission and 1,2,3,5,7 d after treatment.The incidence of multiple organ dysfunction syndrome (MODS) were compared between groups.Results Before treatment,the levels of serum PCT,IL-6,IL-8 and IL-10 were not significantly different between groups (P ＞ 0.05).In both groups,the level of PCT was significantly increased from the first day after onset,reached the peak on the seventh day,the levels of IL-6,IL-8,IL-10 gradually increased from the first day after onset,and reach the peak on the second or third days,then gradually decreased.The serum PCT,IL-6 and IL-8 were significantly lower,the IL-10 was significantly higher 1,2,3,5,7 d after treatment in UTI group than those in control group [PCT:(2.1 ± 0.3) μg/L vs (4.2 ± 0.8) μg/L,(2.3 ± 1.1) μg/L vs (4.4 ± 2.0) μg/L,(2.8±1.0) pg/L vs (5.5±1.3) μg/L,(3.1±1.3) μg/L vs (6.3±1.4) μg/L,(3.2±1.3) μg/L vs (6.6±1.3) μg/L;IL-6:(8.3±2.9) μg/L vs (10.8±1.7) μg/L,(17.8±8.9) μg/L vs (22.6±2.0) μg/L,(15.2±7.6) μg/L vs (30.8 ±6.8) μg/L,(7.8 ±3.4) μg/L vs (23.3 ±3.5) μg/L,(5.3 ±2.2) μg/L vs (12.5 ±2.7) μg/L;IL-8:(167 ±67) μg/L vs (245 ±59) μg/L,(212 ±56) μg/L vs (265 ±64) μg/L,(247 ±54) μg/L vs (387 ±51) μg/L,(164 ±47) μg/L vs (273 ±32) μg/L,(135 ±55) μg/L vs (160 ±21) μg/L,IL-10:(28.5±6.2) μg/L vs (18.9±9.2) μg/L,(32.9±4.1) μg/L vs (20.6±6.4) μg/L,(15.5 ±3.7) μg/L vs (10.5 ±2.9) μg/L,(9.3 ± 1.7) μg/L vs (7.0 ±2.6) μg/L,(8.9 ±2.4) μg/L vs (4.4 ± 1.5) μg/L] (P ＜ 0.05).The incidence of MODS in UTI group was significantly lower than that in control group [7.5 ％ (3/40) vs 15.0％ (6/40)] (P ＜ 0.05).Conclusion Early administration of UTI can effectively decrease the expressions of PCT,IL-6 and IL-8,promote the generation of anti-inflammatory cytokine IL-10,mitigate the nflammatory responses and improve the prognosis in treatment SAP.
Keywords：Severe acute pancreatitisUlinastatinProcalcitoninInterleukin
Publication Date：2016-10-30
Online Publishing Date：2026-09-14(First online date of this platform, not the publication date of the document)
Pages：4( 1498-1501 )