Effects of chromium and magnesium co-supplementation on glucose and lipid metabolism and insulin resistance in impaired glucose regulation people
Zhou Mengmeng
Zhang Fanghua
Li Ying
Gao Shan
Yang Ying
Yao Minxiu
Abstract：Objective To explore the effects of chromium and magnesium supplementation on glucose and lipid metabolism and insulin resistance in impaired glucose regulation people.Methods A total of 180 subjects with impaired glucose regulation from February 2013 to February 2015 were randomly divided into control group,magnesium group and chromium-magnesium group (60 cases in each group).All the patients were orally given vitamin C 400 mg/d,vitamin E 160 mg/d and calcium tablet 500 mg/d;magnesium group was additionally given magnesium 200 mg/d,and chromium-magnesium group was additionally given magnesium 200 mg/d and chromium 160 μg/d;the treatment lasted for 12 weeks.The body mass index,waist to hip ratio,fasting blood glucose (FBG),postprandial 2 h glucose (2 h PG),fasting insulin (FINS),homeostasis model assessment of insulin resistance index (HOMA-IR),total cholesterol,triglyceride,low density lipid protein cholesterol (LDL-C),high density lipoprotein cholesterol (HDL-C) before and after treatment were compared among groups.The hypoglycemia event and adverse drug reactions were recorded.Results A total of 168 subjects completed 12 weeks of treatment,including 55 cases in control group,57 cases in magnesium group and 56 cases in chromium-magnesium group;7 subjects were lost to follow-up and 5 cases were not completed the trail.After 12 weeks of treatment,the levels of FBG and FINS in magnesium group and chromium-magnesium group were significantly lower than those in control group [FBG:(5.33 ± 0.63),(5.02 ± 0.14) mmol/L vs (6.38 ± 1.17) mmol/L;FINS:(11 ± 6),(9 ± 5) mU/L vs (12 ± 6) mU/L] (P ＜ 0.05);the 2 h PG after treatment in chromium-magnesium group was significantly lower than that before treatment [(7.5 ± 2.6) mmol/L vs (9.5 ± 1.0) mmol/L] (P ＜ 0.01);after treatment,the HOMA-IR in magnesium group and chromium-magnesium group,especially in chromium-magnesium group,was significantly lower than that in control group [(2.5 ± 1.3),(2.1 ±1.2) vs (2.8 ±2.3)] (P ＜0.05);after treatment,the 2 h PG and waist to hip ratio in chromium-magnesium group were significantly lower than those in control group [(7.5 ± 2.6) mmol/L vs (9.0 ±1.8) mmol/L,(0.84 ± 0.06) mmol/L vs (0.90 ± 0.07) mmol/L] (P ＜ 0.05).The body mass index,total cholesterol and LDL-C were not significantly changed after treatment in all the groups (P ＞ 0.05);in chromium-magnesium group,the triglyceride was significantly lower after treatment than that before treatment,the HDL-C was significantly higher after treatment than that before treatment and that in control group [triglyceride:(1.1 ±0.5) mmol/L vs (2.1±0.8) mmol/L;HDL-C:(1.7±0.5) mmol/L vs (1.2±0.4),(1.4±0.3) mmol/L](P ＜ 0.05).Conclusion Chromium and magnesium supplementation can improve the glycaemic and lipid metabolism,insulin resistance in impaired glucose tolerance people,and the safety is good.
Keywords：Impaired glucose regulationInsulin resistanceChromiumMagnesiumGlucose
Publication Date：2016-10-30
Online Publishing Date：2026-09-14(First online date of this platform, not the publication date of the document)
Pages：5( 1493-1497 )