Related factors of hypokalemia in treatment of thyroid associated ophthalmopathy with large dose methylprednisolone intravenous pulse therapy
Du Qingfu
Li Yuanyuan
Wu Xiawen
Guan Qingbo
Zhou Xinli
Zhao Jiajun
Xu Chao
Abstract：Objective To explore the related factors of hypokalemia in the treatment of thyroid associated ophthalmopathy (TAO) with large dose methylprednisolone intravenous pulse therapy.Methods A total of 221 TAO patients treated with methylprednisolone from January 2010 to June 2014 were enrolled and divided into hypokalemia group and normal kalium group according to the serum potassium concentration after treatment of methylprednisolone.The general informations were compared between groups and the multivariate Logistic regression analysis was used to analyze relative factors.Results In 221 cases,14 cases (6.3％) had hypokalemia (hypokalemia group) and 207 cases had normal blood potassium (normal potassium group).Before treatment,the smoking proportion,course and thyroid peroxidase antibody were significantly higher or longer in hypokalemia group than those in normal potassium group [57.1％ (8/14) vs 25.1％ (52/207),7.50 (1.75,27.00)months vs 3.00 (1.00,12.00) months,103.70 (23.90,600.00) kIU/L vs 85.14 (28.00,417.30) kIU/L](P ＜ 0.05);the other indicators were not significantly different between groups (P ＞ 0.05).Multivariate Logistic regression analysis showed that smoking was the risk factor of hypokalemia (odds ratio =4.026,95％ confidence interval:1.248-12.981) and serum sodium was the protective factor of hypokalemia (odds ratio =0.977,95％ confidence interval:0.971-0.984).Conclusion Smoking is the risk factor of hypokalemia caused by large dose methylprednisolone intravenous pulse therapy in TAO patients,while the level of serum sodium may be a protective factor.
Keywords：Thyroid associated ophthalmopathyMethylprednisoloneHypokalemiaRisk factors
Publication Date：2016-01-01
Online Publishing Date：2026-09-14(First online date of this platform, not the publication date of the document)
Pages：5( 1485-1489 )