Effect of risperidone on improvement of mental disorders induced by craniocerebral injury
Ma Xiaoqiang
Maimaijiang Abulizi
Xu Minhua
Abstract：Objective To observe the effect of risperidone on improvement mental disorders induced by craniocerebral injury.Methods Totally 98 patients with craniocerebral injury from January 2012 to March 2015 were enrolled;among them,65 patients with mental disorders were randomly divided into observation group (33 cases) and control group (32 cases),the other 33 patients without mental disorders were as blank group.Routine treatment were used in all the patients.Observation group was orally given risperidone (initial dose 0.5 mg/time,2 times/d,gradually increased to 1 mg/time,2 times/d);control group was orally given sulpiride (initial dose 100 mg/time,3 times/d,gradually increased to 200-300 mg/time,3 times/d);the treatment lasted for 8 weeks.The National Institutes of Health Stroke Scale (NIHSS),Brief Psychiatry Rating Scale (BPRS) and Activities of Daily Living Scale (ADL) score before treatment and 2,4,8 weeks after treatment were compared among groups.Results The NIHSS and BPRS score were significantly higher,the ADL score was significantly lower in control group and observation group than those in blank group before treatment [(18.3 ±2.1),(18.2 ±2.4) scores vs (15.6±2.3) scores,(92.5 ±3.4),(92.3 ±3.6) scores vs (28.6 ±2.2) scores,(35 ±6),(34 ± 8) scores vs (43 ± 7) scores] (P ＜ 0.05),while were not significantly different between observation group and control group (P ＜ 0.05).Along with time,the NIHSS and BPRS score were gradually reduced and the ADL score was gradually increased,2,4 and 8 weeks after treatment,they were all significantly different with those before treatment [blank group:(11.5 ± 1.2),(8.4 ± 0.7),(6.2 ± 0.2) scores vs (15.6 ± 2.3) scores,(23.5±2.5),(19.5±1.7),18.2±1.3) scores,(53±10),(64±13),(82±13) scores;control group:(14.8±1.4),(12.1 ±1.4),(8.4 ±0.3) scores,(73.1 ±3.5),(37.2 ±2.5),(27.2 ±2.5) scores,(42±9),(55±11),(72±13) scores;observation group:(14.4±1.8),(10.4±1.6),(6.6±0.5) scores,(72.4±3.8),(31.4±2.3),(19.1±1.4) scores,(47±9),(63±12),(84±12) scores] (all P＜0.05);4 and 8 weeks after treatment,the NIHSS and BPRS score in observation group were significantly lower than those in control group,2,4 and 8 weeks after treatment,the ADL score in observation group was significantly higher than that in control group (P ＜ 0.05);8 weeks after treatment,the NIHSS,BPRS and ADL score in observation group were not significantly different with those in blank group (P ＞ 0.05) Conclusion Risperidone has good curative effect in craniocerebral injury patients with mental disorders,that in can promote nerve functional recovery,reduce mental score and improve life quality.
Keywords：Craniocerebral injuryRisperidoneMental disordersNerve function
Publication Date：2016-10-30
Online Publishing Date：2026-09-14(First online date of this platform, not the publication date of the document)
Pages：4( 1477-1480 )