Levels of serum matrix metalloproteinase-9 and tissue inhibitor of metalioprpteinase-1 in patients with cerebral hemorrhage and their correlations with cerebral edema
Dong Yongjun
Tian Dezhou
Song Feixia
Abstract：Objective To explore the levels of serum matrix metalloproteinase-9 and tissue inhibitor of metalloprpteinase-1 in patients with cerebral hemorrhage and their correlations with cerebral edema.Methods Totally 78 patients with cerebral hemorrhage (cerebral hemorrhage group) and 78 healthy subjects (control group) from April 2013 to March 2015 were enrolled.The levels of serum MMP-9 and TIMP-1 of control group and cerebral hemorrhage group within 24 h after hemorrhage and 3,5,7 and 14 d after hemorrhage were measured;CT examination was performed in cerebral hemorrhage group at above time points.The correlations between MMP-9 and TIMP-1 with edema volume were analyzed.Results The MMP-9 level in cerebral hemorrhage group within 24 h after hemorrhage and 3,5,7,14 d after hemorrhage was significantly higher than that in control group [(226 ±31),(246 ±32),(254 ±34),(240±32),(227 ±31) μg/L vs (54 ±8) μg/L] (P ＜0.05 or P ＜0.01);it reached the peak 5 d after hemorrhage and then was gradually decreased.The TIMP-1 level in cerebral hemorrhage group within 24 h after hemorrhage and 3,5,7 d after hemorrhage was significantly higher than that in control group [(176±21),(254±23),(270±24),(200±21) μg/L vs (80±9) μg/L] (P＜0.05 or P＜0.01);it reached the peak 5 d after hemorrhage,then was gradually decreased,and was not significantly different with that in control group 14 d after hemorrhage.Within 24 h after hemorrhage and 3,5,7,14 d after hemorrhage,MMP-9 was positively correlated with brain edema volume (r =0.742,0.783,0.835,0.754,0.693;P ＜0.01 or P ＜ 0.05);TIMP-1 and brain edema volume was negatively correlated within 24 h after hemorrhage and 7 d after hemorrhage (r =-0.455,-0.231;both P ＜ 0.05),was positively correlated 3 and 5 d after hemorrhage,and was not correlated 14 d after hemorrhage (P ＞ 0.05).Conclusion MMP-9 may be involved in all stages of cerebral edema formation,TIMP-1 may be involved in early brain edema formation only,so MMP-9 can better reflect the brain edema formation.
Keywords：Intracerebral hemorrhageMatrix metalloproteinase-9Tissue Inhibitor of metalloprpteinase-1
Publication Date：2016-10-30
Online Publishing Date：2026-09-14(First online date of this platform, not the publication date of the document)
Pages：4( 1473-1476 )