Differential diagnostic value of T-lymphocyte subsets and adenosine deaminase activity in bronchoalveolar lavage fluid for pulmonary tuberculosis and lung cancer
Liu Ning
Su Mingxia
Li Wen
Yang Yonghui
Xie Lanpin
Fu Hongyi
Abstract：Objective To investigate differeutial diagnostic value of T-lymphocyte subsets and adenosine deaminase(ADA) activity in bronchoalveolar lavage fluid for pulmonary tuberculosis and lung cancer.Methods Fourty-four patients with pulmonary tuberculosis (pulmonary tuberculosis group) and 28 patients with lung cancer(lung cancer group) from August 2009 to December 2014 in Chest Hospital of Hebei Province were enrolled.Levels of T-lymphocyte subsets and activity of ADA in bronchoalveolar lavage fluid were tested.The receiver operator characteristic (ROC) curve was drawn.The diagnostic sensitivity and specificity of CD4 cell and ADA activity for pulmonary tuberculosis were analyzed.Results The levels of CD4,value of CD4/CD8 and activity of ADA in pulmonary tuberculosis group were all significantly higher than those in lung cancer group[(41 ± 4)％ vs (34 ± 4) ％,(1.55 ± 0.20) vs (1.19 ± 0.23),(59 ± 20) U/L vs (26 ± 18) U/L] (P ＜ 0.01);the level of CD4 had no significant difference(P ＞ 0.05).According to ROC curve,the area under curve(AUC) of CD4 was 0.894 [95％ confidence interval (CI):0.811-0.978];the optimal threshold was 37.23 ％;the sensitivity and specificity of pulmonary tuberculosis diagnosis were respectively 77.27％ and 85.71％;the AUC of ADA activity was 0.874 (95％CI:0.786-0.964);the optimal threshold was 34.23 U/L;the sensitivity and specificity of pulmonary tuberculosis diagnosis were respectively 81.82％ and 75.00％.Conclusions The level of CD4 cell and activity of ADA in bronchoalveolar lavage fluid have significant differences between pulmonary tuberculosis and lung cancer.Detections of CD4 and ADA activity have a certain value in the differential diagnosis of pulmonary tuberculosis and lung cancer.
Keywords：Pulmonary tuberculosisLung cancerBronchoalveolar lavage fluidT-lymphocyte subsetsAdenosine deaminase
Publication Date：2016-01-01
Online Publishing Date：2026-09-14(First online date of this platform, not the publication date of the document)
Pages：4( 1469-1472 )