Effect of andrographolidume on serum inflammatory markers in patients with lung infection and clinical curative effect observation
Liu Wei
Jia Jinhu
Abstract：Objective To explore the effect of andrographolidume on serum inflammatory markers in patients with lung infection and observe the clinical curative effect.Methods Totally 100 patients with lung infection from September 2013 to January 2015 were enrolled and randomly divided into observation group and control group (50 cases in each).Based on symptomatic treatment,both groups were intravenously dripped with ambroxol hydrochloride injection (30 mg,1 time/d),observation group was additionally given intravenous drip of andrographolide sulfonate ester (250 mg,1 time/d).The treatment lasted for 10 d.The interleukin-6 (IL-6),procalcitonin (PCT),white blood cell count (WBC),neutrophilic granulocyte percentage were compared between groups before and 3,7,10 d after treatment;the improvement of cough,sputum,fever,dyspnea and pulmonary infection absorption were also compared between groups before and 10 d after treatment.Results Before treatment,the IL-6,PCT,WBC and neutrophilic granulocyte percentage were not significantly different between groups (P ＞0.05).The IL-6 and PCT 3,7,10 d after treatment,the WBC and neutrophilic granulocyte percentage 7 d after treatment were significantly lower than in observation group than those in control group,in observation group were significantly lower than that in control group[IL-6:(26 ±5) ng/L vs (28 ±4) ng/L,(20 ±7) ng/L vs (22 ±4) ng/L,(12±5) ng/Lvs (14±5) ng/L;PCT:(2.09±0.48) μg/L vs (3.28±0.46) μg/L,(1.39±0.42) μg/L vs (2.92 ±0.38) μg/L,(0.60 ±0.12) μg/L vs (2.01 ±0.29) μg/L;WBC:(6.8 ± 1.8) ×109/L vs (8.1 ±2.2) × 109/L;neutrophilic granulocyte percentage:(65.5 ± 1.8)％ vs (68.2 ±7.7)％] (P ＜0.05).Before treatment,the symptom integrals of cough,sputum,fever,and dyspnea and proportion of abnormality in X-ray were not significantly different between groups;10 d after treatment,the symptom integrals of cough,sputum,fever,and dyspnea were significantly increased,the proportion of abnormality in X-ray was significantly reduced compared with pretreatment in both groups [observation group:(2.48 ±0.52) scores vs (1.01 ±0.59) scores,(2.67 ±0.01) scores vs (1.14 ±0.96) scores,(2.77 ±0.20) scores vs (1.02 ±0.16) scores,(2.38 ± 0.12) scores vs (1.57±0.14) scores,24.0％ (12/50) vs 86.0％ (43/50);control group:(2.02 ±0.55) scores vs (1.27 ± 1.05) scores,(2.00 ± 0.48) scores vs (1.25 ± 0.28) scores,(2.04 ± 0.31) scores vs (1.04±0.17) scores,(2.04 ±0.24) scores vs (1.48 ±0.13) scores,60.0％ (30/50) vs 82.0％ (41/50)],and they were all significantly different between groups (P ＜ 0.05).Conclusion Andrographolidume can significantly decrease the levels of inflammatory markers,improve the clinical symptoms and promote the lung infection absorption in patients with pulmonary infection.
Keywords：Lung infectionAndrographolidumeInterleukin-6Procalcitonin
Publication Date：2016-01-01
Online Publishing Date：2026-09-14(First online date of this platform, not the publication date of the document)
Pages：5( 1455-1459 )