Expression and significance of soluble CD105 in serum and CD105 in tumor tissue in patients with glioma
Tian Shaohui
Xu Lei
Li Panxiang
Zhao Yu
Abstract：Objective To explore the expression and significance of soluble CD105 (sCD105) in serum and CD105 in tumor tissues in patients with glioma.Methods Totally 65 patients with cerebral gliomas from May 2011 to May 2014 were enrolled and divided into lower-level group (Ⅰ-Ⅱ degree,17 cases)and high-level group (Ⅲ-Ⅳ degree,48 cases) according to the pathological type.Forty patients with non-cerebral gliomas disease were selected as control group.The immunohistochemical staining was used to measure the expression of CD105 in tumor/brain tissue;the level of sCD105,interleukin 10 (IL-10),IL-6,tumor necrosis factorα (TNF-α) in serum were measured and compared among three groups.Results The expression rate of CD105 in tumor/brain tissue,the levels of sCD105,IL-10,IL-6,TNF-α in serum were all significantly higher in low-level group and high-level group than those in control group [100.0％ (48/48),76.5％ (13/17) vs 20.0％ (8/40),(26.9 ±3.8),(15.7±2.6) μg/L vs (7.1±2.0) μg/L,(311 ±30),(196±24) ng/L vs (55 ±11) ng/L,(19.4 ±4.4),(9.5±2.1) ng/L vs (4.1 ± 1.5) ng/L,(59 ±9),(47 ±8) ng/L vs (9±4) ng/L],and they were significantly higher than in high-level group than those in low-level group (P＜0.05).The level of sCD105 in serum showed significant positive correlations with IL-10,IL-6 and TNF α (r =0.417,0.402,0.382,all P ＜0.001).Conclusion CD105 in tumor and sCD105 in serum are significantly increased in elderly patients with glioma,and are correlated with the levels of cytokines and gliomas.
Keywords：GliomaEndothelial protein CD105Soluble CD105Cytokine
Publication Date：2016-08-30
Online Publishing Date：2026-09-14(First online date of this platform, not the publication date of the document)
Pages：4( 1161-1164 )