Comparison of blood concentration of anti-tuberculosis drugs in Tibetan and Han patients with pulmonary tuberculosis in Qinghai province
Lyu Ronghua
Wang Yuqing
Liu Hanyun
Feng Xiying
Cui Jinxia
Shi Yingqing
Guan Wei
Abstract：Objective To detect and compare blood concentrations of anti-tuberculosis drugs in Tibetan and Han patients with pulmonary tuberculosis,to provide the theory evidence for clinical rational drug use.Methods Totally 114 cases of pulmonary tuberculosis from December 2013 to May 2014 in Qinghai University Affiliated Hospital and the 4th People's Hospital of Qinghai Province were enrolled,including 69 cases of Tibetan patients and 45 cases of Han patients.At the 7th day of anti-tuberculosis drug use,the high performance liquid chromatography was used to detect blood concentrations of isoniazid,rifampicin and pyrazinamide.Results There were no significant differences of blood concentrations of isoniazid,rifamipicin and pyrazinamide between groups [(13.9±7.7)μg/L vs (10.7 ±5.2) μg/L,(2.0± 1.9)mg/L vs (2.3 ± 1.9)mg/L,(5 973 ±3 281) μg/L vs(6 452 ± 3 563) μg/L] (P ＞ 0.05).Conclusion Same doses of anti-tuberculosis drugs can be used in both Tibetan patients and Han patients.
Keywords：Pulmonary tuberculosisAnti-tuberculosis drugsBlood concentrationTibetanHan
Publication Date：2016-01-01
Online Publishing Date：2026-09-14(First online date of this platform, not the publication date of the document)
Pages：5( 1149-1153 )