Analysis of clinical characteristics and prognosis in patients with Takayasu's arteritis

doi:10.3760/cma.j.issn.1673-4777.2016.08.009

Abstract：Objective To investigate clinical features and prognosis in patients with Takayasu's arteritis.Methods Totally 64 cases of Takayasu's arteritis from January 2010 to December 2011 in Beijing Anzhen Hospital,Capital Medical University were retrospective analyzed,including clinical manifestations,laboratory and imaging examination results,treatments and prognosis.Results ①In 64 cases,the ratio of male to female was 1 ∶ 3.9,the median age of onset was 40.5 years old.②Clinical classifications:extensive arteritis accounted for 40.6％ (26/64),brachiocephalic arteritis accounted for 32.8％ (21/64),abdominal aorta arteritis accounted for 25.0％ (16/64),pulmonary artery arteritis accounted for 1.6％ (1/64).③The most common clinical manifestations were hypertension,pain in perivascular affected areas,dizziness,weakness,pulseless,fever,hemoptysis,etc.④Laboratory examination showed that 35.9％ (23/64) patients had elevated erythrocyte sedimentation rates,25.0％ (16/64) patients had elevated C-reactive protein levels.Imaging examination showed that vascular stenosis or occlusion was major lesion.⑤In the 64 casess,40 patients were treated with drugs and 24 patients received surgical treatments.⑥The follow-up was completed in 51 cases;in 35 cases with hormone therapy,30 patients got better,2 patients had no obvious improvement,3 patients got worse;in 16 cases with surgical treatment,all vascular prosthesis were clear.There was no death case.Conclusions The most common clinical manifestation of Takayasu's arteritis is hypertension and pain in affected areas.Laboratory and imaging examinations can help diagnosis clinical classifications.Hormone therapy is effective in the remission of disease;surgical treatment should be used in patients with poor curative effects in drug treatment and patients with vascular stenosis or occlusion.