Relationship between stent restenosis and retinopathy in patients with type 2 diabetes mellitus

Shi Xinguo; Shen Hongli

doi:10.3760/cma.j.issn.1673-4777.2016.08.003

Abstract：Objective To explore the relationship between stent restenosis and retinopathy in patients with type 2 diabetes mellitus (T2DM).Methods A total of 408 patients with T2DM who underwent coronary stent implantation from June 2010 to June 2014 were enrolled.The patients were divided into two groups,restenosis group(123 cases) and non-restenosis (285 cases),and three groups according to retinopathy stages,non-diabetic retinopathy group (279 cases),background phase group (81 cases),proliferative phase group (48 cases).The risk factors of stent restenosis and diabetic retinopathy were analyzed,the correlation between stent restenosis and diabetic retinopathy was assessed.Results Compared with those in non-restenosis group,the duration of T2DM and hemoglobin A1c (HbA1c) in restenosis group were significantly longer and higher [(117 ± 17) months vs (149-±19) months,(8.4 ± 2.1) ％ vs (9.7 ± 2.2) ％] (P ＜ 0.05).Logistic stepwise multiple regression analysis showed that the independent risk factors for stent restenosis included duration of T2DM ≥ 10 years,HbA1c ≥7.5％,smoking,bifurcation lesion,calcified lesion,overlapping stent implantation.The proportion of smoking,duration of T2DM,HbA1c and stent restenosis ratio among non-diabetic retiuopathy group,background phase group and proliferative phase group were significantly different [30.5％ (85/279) vs 45.7％ (37/81),50.0％(24/48),(149 ± 109) months vs (189 ± 111) months,(219 ± 122) months,(8.1 ±4.1)％ vs (8.5 ±2.7) ％,(9.2 ± 3.6) ％,22.2 ％ (62/279) vs 42.0％ (34/81),56.2％ (27/48)] (P ＜ 0.05).The independent risk factors for diabetic retinopathy included smoking,duration of T2DM ≥ 10 years and HbA1c.Conclusion The proportion of stent restenosis increased along with severity of diabetic retinopathy.