Efficacy and safety of dual-antiplatelet therapy on transient ischemic attack
Liu Chunjie
Zheng Hailiang
Li Xiaoqing
Abstract：Objective To analyze the efficacy and safety of dual-antiplatelet therapy with aspirin and clopidogrel treating transient ischemic attack(TIA).Methods Totally 120 patients with TIA from January 2012 to January 2014 in Beijing Anzhen Hospital,Capital Medical University were analyzed,a retrospective analysis was conducted.All patients were divided into 2 groups:mono-anti group(60 cases,aspirin 100mg/d or clopidogrel 75mg/d)and dual-anti group(60 cases,aspirin 100mg/d and clopidogrel 75mg/d).Gender,age,medical history,imaging data,the progression of disease(develop to cerebral infarction or not) at 7 and 21d after treatment and adverse reactions (cerebral hemorrhage,gastrointestinal bleeding,gingival bleeding,mucocutaneous hemorrhage)were observed.Results There were no significant differences in gender,age,history of hypertension,hyperlipidemia,diabetes,smoking,drinking,cerebral infarction and cerebral hemorrhage between groups (P ＞0.05).At 7 and 21d after treatment,rates of cerebral infarction in dual-anti group were significantly lower than those in mono-anti group[1.7％ (1/60) vs 11.7％ (7/60),3.3％ (2/60) vs 13.3％ (8/60)] (P ＜0.05).At 7d after treatment,no bleeding occurred in 2 groups;At 21d after treatment,there were 3 cases of bleeding in dual-anti group and 2 cases in mono-anti group;the difference between groups was not significant (P ＞ 0.05).Conclusion Dual-antiplatelet therapy with aspirin and clopidogrel on TIA is safe and effective.
Keywords：Transient ischemic attackAspirinClopidogrel
Publication Date：2016-01-01
Online Publishing Date：2026-09-14(First online date of this platform, not the publication date of the document)
Pages：4( 1008-1011 )