Analysis of combined detection and screening of lung cancer tumor markers for rural citizens in "New Rural Cooperative Medical System" in Beijing Pinggu district
Zhang Xin
Liu Qian
Xie Zhixian
Abstract：Objective To analyze the detection and screening results of lung cancer tumor markers for rural citizens in" New Rural Cooperative Medical System" in Beijing Pinggu district.Methods Totally 11 258people with ages of 35-75 in" New Rural Cooperative Medical System" from January 2012 to December 2013 in Beijing Pinggu district were selected.Clinical symptoms were observed and serum levels of carcino-embryonic antigen(CEA),Squamous cell carcinoma antigen(SCC) were detected to screen lung cancer which was finally diagnosed by low dose spiral CT and pathological examination.The occurrence of lung cancer and age,risk factors distribution,levels and positive expressions of CEA and SCC were analyzed.Results In 11 258 people,totally 22 cases(0.2％)were diagnosed of lung cancer(lung cancer group),including 20 males and 2 females;totally 7018 cases (62.3％)were diagnosed of benign lung disease (benign long disease group),including 5671 males and 1 347 females;other 4 218 healthy people(37.5％)were enrolled as health control group,including 2 421males and 1797 females.People over 65 years old had the highest proportion of lung cancer,which was 59.1％(13/22).Incidences of lung cancer between male and female in people with ages of 35-50,51-65 and over 65 had statistically significant differences [0.20‰ (2/11 258) vs 0.00‰ (0/11 258),0.50‰ (6/11 258) vs 0.09‰ (1/11 258),1.10‰(12/11 258) vs 0.09‰(1/11 258)] (P ＜ 0.05).The main risk of lung cancer among rural citizens in Pinggu district was age,followed by smoking and environmental factors.Levels of CEA and SCC in lung cancer group were significantly higher than those in benign lung disease group and healthy control group[(25.6 ±3.2)μg/L vs(3.2 ±0.9),(3.4 ±0.8)μg/L;(2.3±0.7)μg/L vs(1.3 ±0.3),(0.8 ±0.3)μg/L](P＜0.05).Positive expressions of CEA and SCC with combined detection were significantly higher than those in separate detection[86.4％ (19/22) vs 72.7％ (16/22),63.6％ (14/22)] (P ＜0.05).Conclusion Combined detection of serum CEA and SCC can significantly improve diagnostic sensitivity of lung cancer and provide valuable screening information for patients in "New Rural Cooperative Medical System".
Keywords：Lung cancerTumor markerNew rural cooperative medical system
Publication Date：2016-01-01
Online Publishing Date：2026-09-14(First online date of this platform, not the publication date of the document)
Pages：4( 1000-1003 )