Relation between polymorphism of vascular endothelial growth factors gene and risk of ventricular septal defect
Li Wenxiu
Geng Bin
Su Junwu
Wu Jiang
Yang Shuang
Liu Yinglong
Abstract：Objective To investigate the relation between polymorphism of vascular endothelial growth factors(VEGF) gene and risk of ventricular septal defect (VSD).Methods Sixty-eight children of isolated VSD (VSD group)and 78 cases of non-congenital heart disease (control group)were enrolled from January 2013 to December 2014 in Beijing Anzhen Hospital,Capital Medical University.Polymerase chain reaction and DNA sequencing technique were used to detect 5 loci of VEGF gene (-2578C ＞ A,-460T ＞ C,-1154G ＞ A,+ 405G ＞ C,+ 936C ＞ T).The polymorphism of VEGF gene was genotyped,effects of its allelic gene and genotypic frequency on the risk of VSD were analyzed.Results The G/G genotype of VEGF + 405G ＞ C had profective effect on VSD[odds ratio(OR) =0.31,95％ confidence interval (CI) =0.14-0.67,P ＜ 0.01);the C/C genotype of VEGF + 405G ＞ C had risk effect on VSD (OR =2.69,95％ CI =1.07-6.77,P ＜ 0.05),the C/C genotype was a predisposing genotype of VSD.The A haplotype of VEGF-1154G ＞ A (OR =0.41,95％ CI =0.23-0.76,P ＜0.01) and G haplotype of VEGF + 405G ＞ C (OR =0.47,95％ CI =0.29-0.75,P ＜ 0.01) had positive effect on VSD;the C haplotype of VEGF + 405 G ＞ C had risk effect on VSD (OR =2.13,95 ％ CI =1.33-3.40,P ＜ 0.01),the C haplotype was a predisposing haplotype of VSD.Conclusion Genic mutations of VEGF-1154G ＞ A and +405G ＞C are related to the risk of VSD.
Keywords：Heart septal defects,ventricularVascular endothelial growth factorGene variabilityCongential heart disease
Publication Date：2016-07-30
Online Publishing Date：2026-09-14(First online date of this platform, not the publication date of the document)
Pages：4( 988-991 )